ALMS1 and CNOT7

		ALMS1	CNOT7
Description		ALMS1 centrosome and basal body associated protein	CCR4-NOT transcription complex subunit 7
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Mitochondrion Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Ciliary Basal Body Cell Projection	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Endosomal Transport Regulation Of Centriole Replication Regulation Of Stress Fiber Assembly Positive Regulation Of Cold-induced Thermogenesis	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Translation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Viral Genome Replication Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases		Alstrom syndrome (AS)
GWAS		Age at voice drop ( 27182965) Blood metabolite levels ( 26401656) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31451708 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) High density lipoprotein cholesterol levels ( 33339817) Intelligence (MTAG) ( 29326435) Menarche (age at onset) ( 27182965) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Retinitis pigmentosa ( 33514863) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		3 interacting genes: GTF2IRD1 LIG4 MEGF10	29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI OBI1 PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101
Entrez ID		7840	29883
HPRD ID		06023	05370
Ensembl ID		ENSG00000116127	ENSG00000198791
Uniprot IDs		Q8TCU4	Q96IQ6 Q9UIV1
PDB IDs			2D5R 4GMJ 7AX1 7VOI
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteolysis Histone Kinase Activity Proteasome-activating Activity Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Phorbol 13-acetate 12-myristate Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm CCR4-NOT Complex
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