RAP2B and PRKAR2B

		RAP2B	PRKAR2B
Description		RAP2B, member of RAS oncogene family	protein kinase cAMP-dependent type II regulatory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Bicellular Tight Junction Endomembrane System Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Platelet Activation Negative Regulation Of Cell Migration Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Neutrophil degranulation	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: CAMK2B PDE6D RAB40B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12
Entrez ID		5912	5577
HPRD ID		01548	01486
Ensembl ID		ENSG00000181467	ENSG00000005249
Uniprot IDs		P61225	B3KY43 P31323
PDB IDs		1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction GTPase Regulator Activity Signal Transduction Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Intracellular Signal Transduction CAMP Binding Positive Regulation Of Neuron Projection Development Intracellular Signaling Cassette Neurotrophin Signaling Pathway Establishment Of Endothelial Barrier Nervous System Development Endothelial Cell Development Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Neuron Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To CAMP Regulation Of Cell Projection Organization CAAX-box Protein Maturation Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Projection Organization Response To CAMP Positive Regulation Of GTPase Activity Response To Antipsychotic Drug Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Dendrite Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Beta-1 Adrenergic Receptor Binding Regulation Of Neuron Projection Development Positive Regulation Of Hydrolase Activity Myosin Filament Assembly Brain-derived Neurotrophic Factor Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Calcium- And Calmodulin-dependent Protein Kinase Complex System Development Modulation Of Chemical Synaptic Transmission Regulation Of GTPase Activity Epithelial Cell Development Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Microvillus Assembly Response To Purine-containing Compound Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Synapse Structural Plasticity CAMP-dependent Protein Kinase Regulator Activity	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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