RRP9 and SIRT7

Number of citations of the paper that reports this interaction (PubMedID 26867678)
51

Data Source:
BioGRID (enzymatic study)

		RRP9	SIRT7
Description		ribosomal RNA processing 9, U3 small nucleolar RNA binding protein	sirtuin 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Nucleolus Organizer Region Cytoplasm Nuclear Speck Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding U3 SnoRNA Binding	Chromatin Binding Protein Binding Protein Methyltransferase Activity Transferase Activity Hydrolase Activity NAD-dependent Protein Lysine Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity
	Biological Process	RRNA Processing Ribosomal Small Subunit Biogenesis	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Protein Deacetylation DNA Damage Response Homologous Chromosome Pairing At Meiosis RRNA Transcription Transposable Element Silencing Regulation Of Mitochondrion Organization Negative Regulation Of Protein Ubiquitination Epigenetic Regulation Of Gene Expression Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Gluconeogenesis Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Protein Export From Nucleus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Deglutarylation R-loop Processing Protein Depropionylation DNA Repair-dependent Chromatin Remodeling Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of RRNA Processing
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: CSNK2A1 RAP2A SIRT7 SMURF1	14 interacting genes: APP H2AC20 H2BC21 H3C1 H4C1 KAT2B MAGED1 NPM1 POLR1E PPARG RRP9 USP17L2 USP39 WDR77
Entrez ID		9136	51547
HPRD ID		08827	12094
Ensembl ID		ENSG00000114767	ENSG00000187531
Uniprot IDs		O43818	Q9NRC8
PDB IDs		4J0W 4JXM 7MQ8 7MQ9 7MQA	5IQZ 6G0S 9GMK 9GMR
Enriched GO Terms of Interacting Partners?		Protein Targeting To Vacuole Involved In Autophagy Regulation Of Cellular Response To Stress Protein Localization To Vacuole Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Nucleolus Organizer Region Protein-glutaryllysine Deglutarylase Activity Engulfment Of Target By Autophagosome Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Intracellular Signal Transduction Positive Regulation Of Aggrephagy Positive Regulation Of Microvillus Assembly Protein Targeting Sulfatide Binding Activin Receptor Binding Regulation Of DNA Repair Regulation Of Anatomical Structure Morphogenesis Endolysosome ATF6-mediated Unfolded Protein Response NAD-dependent Protein Lysine Deacetylase Activity Substrate Localization To Autophagosome Positive Regulation Of Growth Positive Regulation Of RRNA Processing R-loop Processing Rap Protein Signal Transduction Regulation Of Microvillus Assembly Sarcoplasmic Reticulum Lumen Wnt Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Aggrephagy Regulation Of Cellular Component Organization Signal Transduction Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Protein Localization To Organelle Positive Regulation Of Systemic Arterial Blood Pressure Low-density Lipoprotein Particle Receptor Activity Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of RRNA Processing Protein Deacetylation Protein Methyltransferase Activity	Chromatin Remodeling Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleus Chromatin Organization Protein-containing Complex Assembly Nucleosome Assembly Nucleosome Nucleosome Organization Protein-containing Complex Organization Protein Heterodimerization Activity Negative Regulation Of Cell Population Proliferation Protein-containing Complex Negative Regulation Of Centrosome Duplication Epigenetic Regulation Of Gene Expression Transcription Coactivator Activity Negative Regulation Of Gene Expression Regulation Of Cell Population Proliferation Positive Regulation Of Glycolytic Process Nucleoplasm Regulation Of Centriole Replication Negative Regulation Of MiRNA Transcription Cellular Component Assembly Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of RNA Splicing DNA-binding Transcription Factor Binding Positive Regulation Of Fatty Acid Metabolic Process Chromatin Binding Regulation Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium DNA Binding Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Centrosome Duplication RNA Polymerase I General Transcription Initiation Factor Binding Oocyte Axis Specification Macromolecule Metabolic Process
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