RAP1GDS1 and NRAS

Number of citations of the paper that reports this interaction (PMID 11948427)
6

Data Source:
HPRD (two hybrid, in vitro)

		RAP1GDS1	NRAS
Gene Name		RAP1, GTP-GDP dissociation stimulator 1	neuroblastoma RAS viral (v-ras) oncogene homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome	Golgi Membrane Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity	GTP Binding Protein Complex Binding
	Biological Process	Vascular Smooth Muscle Contraction Myosin Filament Assembly Positive Regulation Of Rho GTPase Activity Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Mitochondrial Calcium Ion Concentration	MAPK Cascade Activation Of MAPKK Activity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Skeletal Muscle Tissue Development Leukocyte Migration Striated Muscle Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS		Biochemical measures ( 19260141)
Protein-Protein Interactions		13 interactors: CDC42 DOC2A EGFR HRAS KIFAP3 KRAS MBIP NRAS PLEKHB1 RAC1 RAP1A RHOA ZNF451	19 interactors: ACVR1 ARHGAP4 BCL2 DNAJB1 EEF1A1 PIK3CA PIK3CG PLCE1 RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RPS20 SHOC2 SMAD4 SMURF2 SRI
Entrez ID		5910	4893
HPRD ID		11763	01273
Ensembl ID		ENSG00000138698	ENSG00000213281
Uniprot IDs		B3KNU0 P52306 Q6U7G8	P01111 Q5U091
PDB IDs			3CON
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Activation Of MAPKK Activity Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Response To Wounding Positive Regulation Of Rac Protein Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway Axonogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Neuron Projection Morphogenesis Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Epithelium Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of DNA Replication Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Ras Protein Signal Transduction Neuron Projection Development Regulation Of Phosphorylation Immune Response-regulating Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Cell Migration Cell Projection Morphogenesis	Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Ras Protein Signal Transduction Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cardiovascular System Development Cellular Response To Organic Substance Regulation Of Growth Regulation Of Cell Growth Response To Organic Substance Endocardial Cell Differentiation Positive Regulation Of Hydrolase Activity Cell Activation Regulation Of Protein Phosphorylation Response To Wounding Cell Proliferation Cellular Metal Ion Homeostasis Positive Regulation Of GTPase Activity Platelet Activation Blood Coagulation Hemostasis Cellular Cation Homeostasis Regulation Of GTPase Activity Cellular Ion Homeostasis Metal Ion Homeostasis Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Peptidyl-serine Phosphorylation BMP Signaling Pathway Stem Cell Development
Tagcloud ?		adapted af4 aml1 b2a2 b3a2 considerations consuming correspondence e1a2 e2a enl evaluable expensive laborious leukemic lymphoblastic mll multicenter multiplex nup98 p190 p210 pallisgaard pbx1 rt sil strengthen tal1 tel	12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Difference) ?		adapted af4 aml1 b2a2 b3a2 considerations consuming correspondence e1a2 e2a enl evaluable expensive laborious leukemic lymphoblastic mll multicenter multiplex nup98 p190 p210 pallisgaard pbx1 rt sil strengthen tal1 tel	12v2 altering atrx banding beadchip bon constitution cytosnp exome frameshift gtg heterozygosity hiseq homozygous ilumina implicating indels lubrication muc neuroendocrine ngs ploidy pnet qgp sanger sequenced snvs stretches toolkit
Tagcloud (Intersection) ?