RAP1GDS1 and RNF19B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAP1GDS1	RNF19B
Description		Rap1 GTPase-GDP dissociation stimulator 1	ring finger protein 19B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Cytolytic Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cardiac Muscle Hypertrophy Regulation Of Mitochondrion Organization Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Localization To Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of ERK5 Cascade CAAX-box Protein Maturation Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Matrix Metallopeptidase Secretion	Adaptive Immune Response Immune System Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		23 interacting genes: AKT1 CDC42 DIRAS1 DOC2A EGFR HRAS KIFAP3 KRAS LCOR MBIP NRAS OGT PLEKHB1 PTPRF PUF60 RAC1 RAP1A RAP2B RHOA RNF19B RRAS2 UBC ZNF451	30 interacting genes: APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 SLC61A1 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3
Entrez ID		5910	127544
HPRD ID		11763	13725
Ensembl ID		ENSG00000138698	ENSG00000116514
Uniprot IDs		B3KNU0 P52306 Q6U7G8	Q6ZMZ0
PDB IDs		5XGC 5ZHX
Enriched GO Terms of Interacting Partners?		G Protein Activity GTPase Activity GDP Binding GTP Binding Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Glutamatergic Synapse Regulation Of Protein Localization To Membrane Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Locomotion Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorylation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ras Protein Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Positive Regulation Of Epithelial Cell Proliferation Cerebral Cortex Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Process Postsynapse Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Forebrain Radial Glial Cell Differentiation Cell Development Telencephalon Cell Migration Focal Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Positive Regulation Of Cell Cycle Process Cell Migration Forebrain Cell Migration	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ubiquitin Conjugating Enzyme Activity
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