RAG2

Description		recombination activating 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex
	Molecular Function	DNA Binding Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate Binding Histone H3K4me3 Reader Activity
	Biological Process	Mature B Cell Differentiation Involved In Immune Response B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment DNA Recombination Chromatin Organization B Cell Differentiation T Cell Differentiation T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus V(D)J Recombination Organ Growth Defense Response To Bacterium Positive Regulation Of Organ Growth DN2 Thymocyte Differentiation
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Rheumatoid arthritis ( 24390342)
Novel Interacting Genes		3 novel interacting genes: CAPRIN1 LMO2 RCN1
Interacting Genes		4 interacting genes: FOXP1 IPO5 RAG1 SKP2
Entrez ID		5897
HPRD ID		08913
Ensembl ID		ENSG00000175097
Uniprot IDs		P55895
PDB IDs		8T4R
Enriched GO Terms of Interacting Partners?		Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process Double-stranded DNA Endonuclease Activity Negative Regulation Of Leukocyte Apoptotic Process DNA Recombinase Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-21 Production
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