LYRM4 and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LYRM4	NECTIN2
Description		LYR motif containing 4	nectin cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Nuclear Body Mitochondrial [2Fe-2S] Assembly Complex L-cysteine Desulfurase Complex Iron-sulfur Cluster Assembly Complex	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Protein Homodimerization Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Receptor Ligand Activity Cell Adhesion Molecule Binding
	Biological Process	Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cellular Anatomical Entity Morphogenesis Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle Complex III assembly	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Height ( 21998595) Red cell distribution width ( 32888494) Systolic blood pressure ( 31170924)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		1 interacting genes: NECTIN2	38 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE1E LCE1F LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 RGS20 SIAH1 TCF4 TGM1 TIGIT USP53
Entrez ID		57128	5819
HPRD ID		12855	02879
Ensembl ID		ENSG00000214113	ENSG00000130202
Uniprot IDs		C9JRX8 C9JY28 F5H189 Q9HD34	Q92692
PDB IDs		5USR 5WGB 5WKP 5WLW 6NZU 6ODD 6UXE 6W1D 6WI2 6WIH 7RTK 8PK8 8PK9 8PKA 8RMC 8RMD 8RME 8RMF 8RMG 8TVT	3R0N 4DFH 4DFI 4HZA 5V52 8X6B
Enriched GO Terms of Interacting Partners?		Fusion Of Virus Membrane With Host Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Zonula Adherens Spermatid Nucleus Differentiation Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Adhesion Of Symbiont To Host Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Apical Junction Complex Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Cell-cell Contact Zone Regulation Of Viral Entry Into Host Cell Acrosome Assembly Establishment Of Mitochondrion Localization Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immunoglobulin Mediated Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Mitochondrion Localization Regulation Of T Cell Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Immunity Coreceptor Activity Secretory Granule Organization Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Mediated Cytotoxicity Virus Receptor Activity Nucleus Organization Cell Adhesion Molecule Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Spermatid Development Regulation Of T Cell Mediated Immunity Regulation Of Viral Life Cycle	Identical Protein Binding Intermediate Filament Keratinization Epidermis Development Keratin Filament Cell Adhesion Mediator Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Molecule Binding Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Leukocyte Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mast Cell Activation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Adherens Junction Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Innate Immune Response Cell-cell Contact Zone Cochlea Morphogenesis Semicircular Canal Formation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Neuron Apoptotic Process Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway TRNA-dihydrouridine20 Synthase Activity L-cysteine Desulfurase Complex Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
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