USP53

Name	ubiquitin specific peptidase 53
Structure	No pdb structure
Interactors	9 interactors: CRK CRKL DAB1 GRB2 IREB2 NECTIN2 SAMD4B TRAF2 UBC
GO Annotations	Cellular Component	Cell-cell Junction Bicellular Tight Junction Anchoring Junction
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Hydrolase Activity Metal Ion Binding K63-linked Deubiquitinase Activity
	Biological Process	Action Potential Sensory Perception Of Sound Response To Auditory Stimulus Protein Deubiquitination Neuron Apoptotic Process Epithelial Cell Apoptotic Process Outer Hair Cell Apoptotic Process
GWAS	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Body mass index ( 29273807 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	54532
HPRD ID	11669
Ensembl ID	ENSG00000145390
Uniprot IDs	A0A8J9FKG6 Q70EK8 Q9H9I0
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Reelin-mediated Signaling Pathway Signaling Adaptor Activity Helper T Cell Diapedesis Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cerebellar Neuron Development Dendrite Development Phosphotyrosine Residue Binding Regulation Of Lymphocyte Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Diapedesis Hippocampus Development Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Postsynaptic Specialization Assembly Positive Regulation Of Receptor Clustering Cellular Response To Nitric Oxide Regulation Of Receptor Clustering Cellular Response To Reactive Nitrogen Species Positive Regulation Of Rac Protein Signal Transduction Response To Nitric Oxide Neuron Migration Regulation Of Immune Response Postsynaptic Specialization Organization Ephrin Receptor Binding Immune System Process Regulation Of MRNA Stability Regulation Of Rac Protein Signal Transduction Negative Regulation Of Immune Response Protein-macromolecule Adaptor Activity T Cell Migration Regulation Of RNA Stability Vesicle Membrane Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of MAPK Cascade Natural Killer Cell Mediated Immunity Central Nervous System Neuron Development Positive Regulation Of Immune Response Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Migration Small GTPase-mediated Signal Transduction Lymphocyte Migration Negative Regulation Of Defense Response Regulation Of Substrate Adhesion-dependent Cell Spreading Ubiquitin Protein Ligase Binding Regulation Of Cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus