PVR and TNFRSF12A

Number of citations of the paper that reports this interaction (PMID 21982860)
4

Data Source:
BioGRID (pull down)

		PVR	TNFRSF12A
Gene Name		poliovirus receptor	tumor necrosis factor receptor superfamily, member 12A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Ruffle Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity Receptor Activity Protein Binding Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Viral Process Single Organismal Cell-cell Adhesion Cell Migration Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity	Angiogenesis Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Axon Extension Regulation Of Wound Healing Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)
Protein-Protein Interactions		18 interactors: AP1M2 CD226 CD96 DYNLT1 DYNLT3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NOTCH2NL PLA2G3 PVRL1 PVRL3 SLC30A2 TIGIT TNFRSF12A VTN WNK1	9 interactors: PVR PVRL2 RAC1 SLC30A2 TNFSF12 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		5817	51330
HPRD ID		01434	05801
Ensembl ID		ENSG00000073008	ENSG00000006327
Uniprot IDs		P15151	Q9NP84
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3UDW 3URO 4FQP	2EQP 2KMZ 2RPJ
Enriched GO Terms of Interacting Partners?		Cell Adhesion Lens Morphogenesis In Camera-type Eye Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Immune System Process Positive Regulation Of Sequestering Of Zinc Ion Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Adherens Junction Organization Lens Development In Camera-type Eye Anatomical Structure Morphogenesis Cell Differentiation Interaction With Host Organelle Localization Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Wound Healing Camera-type Eye Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Intracellular Transport Of Viral Protein In Host Cell Transport Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Viral Process Eye Morphogenesis Retina Development In Camera-type Eye Enamel Mineralization Positive Regulation Of Immune Response To Tumor Cell Immune Response Viral Life Cycle Developmental Process Immune System Process Cell Junction Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Sperm Axoneme Assembly Tooth Mineralization Cell-cell Junction Organization Cell-substrate Adhesion Positive Regulation Of Systemic Arterial Blood Pressure Lipoxygenase Pathway Desmosome Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Mast Cell Activation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Phosphatidylglycerol Acyl-chain Remodeling Acrosome Assembly Amelogenesis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway	Susceptibility To T Cell Mediated Cytotoxicity Apoptotic Process Positive Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Susceptibility To Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Positive Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell-cell Junction Organization Viral Entry Into Host Cell Entry Into Host Cell Positive Regulation Of Cell Activation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Component Assembly Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of Sequestering Of Zinc Ion Regulation Of Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Immune Response-regulating Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Cell Activation Signal Transduction Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host
Tagcloud ?		advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening	2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak
Tagcloud (Difference) ?		advance catheterization collaborative consensus epoprostenol glaxo hemodynamic investigators mailed multicenter nc nineteen optimize output page pap park pph pulmonary responded routinely scheduled survey thirds triangle unresponsive vasodilator wellcome worsening	2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak
Tagcloud (Intersection) ?