PURA and PURB

Number of citations of the paper that reports this interaction (PMID 10318844)
24

Data Source:
HPRD (in vitro, in vivo)

		PURA	PURB
Gene Name		purine-rich element binding protein A	purine-rich element binding protein B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus DNA Replication Factor A Complex Cytoplasm Dendrite Neuronal Cell Body	Nucleus Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	Translation Repressor Activity, Nucleic Acid Binding Double-stranded Telomeric DNA Binding Single-stranded DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Purine-rich Negative Regulatory Element Binding Poly(A) RNA Binding SMAD Binding	Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity MRNA Binding Transcription Factor Binding Poly(A) RNA Binding SMAD Binding
	Biological Process	DNA Unwinding Involved In DNA Replication DNA Replication Initiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ADAP1 CCNT1 CDK5 E2F1 IL7R PURB RAF1 RB1 SP1 YBX1	3 interactors: CSNK2A1 IL7R PURA
Entrez ID		5813	5814
HPRD ID		02721	12325
Ensembl ID			ENSG00000146676
Uniprot IDs		Q00577	Q96QR8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process MRNA Stabilization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Homeostasis Of Number Of Cells Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Viral Transcription Regulation Of Protein Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Regulation Of Kinase Activity Regulation Of MRNA Stability Regulation Of RNA Stability Neuron Apoptotic Process Signaling Cell Communication Neuron Death Regulation Of Signal Transduction Regulation Of Viral Transcription Regulation Of Cell Cycle Positive Regulation Of Viral Process Death-inducing Signaling Complex Assembly Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Transcription, DNA-templated Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Organ Development Positive Regulation Of Organelle Organization Cellular Response To Organic Substance Programmed Cell Death	Interleukin-7-mediated Signaling Pathway Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of T Cell Mediated Immunity DNA Unwinding Involved In DNA Replication Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Protein Metabolic Process DNA Replication Initiation Negative Regulation Of Adaptive Immune Response Mitotic Spindle Checkpoint B Cell Proliferation Negative Regulation Of Chromosome Segregation System Development Cell Morphogenesis Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Immunoglobulin Production Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Multicellular Organismal Development Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA Recombination Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process DNA Duplex Unwinding DNA Geometric Change Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Positive Regulation Of T Cell Differentiation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Translation Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Chromosome Organization Regulation Of Cell Proliferation Positive Regulation Of Lymphocyte Differentiation
Tagcloud ?		abbott accu aliquoted aviva bayer chek contour electrochemistry freestyle hct hematocrit heparinized lifescan lite lots mard meter meters mylife mystar onetouch performa roche sanofi strip verio xt ypsomed ysi	5q31 7p13 aml balance bands chromosomes concurrent cooperative del deleted deletions delicate egr functionally hemizygously heterodimers localizes mapping monosomy myelogenous nearly pura q31 segment segregation simultaneous telomeric
Tagcloud (Difference) ?		abbott accu aliquoted aviva bayer chek contour electrochemistry freestyle hct hematocrit heparinized lifescan lite lots mard meter meters mylife mystar onetouch performa roche sanofi strip verio xt ypsomed ysi	5q31 7p13 aml balance bands chromosomes concurrent cooperative del deleted deletions delicate egr functionally hemizygously heterodimers localizes mapping monosomy myelogenous nearly q31 segment segregation simultaneous telomeric
Tagcloud (Intersection) ?		pura