PURA and CCNT1

Number of citations of the paper that reports this interaction (PubMedID 11730934)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PURA	CCNT1
Description		purine rich element binding protein A	cyclin T1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Cytoplasm Dendrite Neuronal Cell Body Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity SnRNA Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Initiation Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Negative Regulation Of DNA-templated Transcription Lymphocyte Proliferation Epithelial Cell Proliferation Dendritic Transport Of Messenger Ribonucleoprotein Complex	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Division
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		59 interacting genes: ADAP1 CCNT1 CDK5 E2F1 FILNC1 FOXP1 IL7R MIR1-1 MIR106B MIR122 MIR128-1 MIR128-2 MIR140 MIR143 MIR155 MIR15B MIR16-2 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR7-1 MIR7-2 MIR9-2 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PTEN PURB RB1 SP1 YBX1	24 interacting genes: AFF4 AHR BRD4 CDK9 ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2
Entrez ID		5813	904
HPRD ID		02721	03938
Ensembl ID		ENSG00000185129	ENSG00000129315
Uniprot IDs		Q00577	A8K4M5 O60563
PDB IDs		8CHT 8CHU 8CHV 8CHW	2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Locomotion Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Multicellular Organismal Development Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of Cell Migration Extracellular Space Regulation Of Cell Motility Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression 7SK SnRNA Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation SnRNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Transcription Elongation Factor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process P-TEFb Complex Binding 7SK SnRNP Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA-templated Transcription Rhythmic Process Transcription Regulator Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Protein-containing Complex Positive Regulation Of Fibroblast Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?