KCNA5 and TMEM107

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNA5	TMEM107
Description		potassium voltage-gated channel subfamily A member 5	transmembrane protein 107
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Cell Surface Intercalated Disc Membrane Z Disc Monoatomic Ion Channel Complex Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm	Cilium Membrane Ciliary Transition Zone MKS Complex Cell Projection
	Molecular Function	Signaling Receptor Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Bundle Of His Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Repolarization Scaffold Protein Binding	Protein Binding
	Biological Process	Action Potential Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Notch Signaling Pathway Response To Mechanical Stimulus Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Response To Hydrogen Peroxide Regulation Of Insulin Secretion Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Transmembrane Transport Response To Hyperoxia Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Bundle Of His Cell Action Potential Membrane Repolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation	Detection Of Nodal Flow Determination Of Left/right Symmetry Regulation Of Gene Expression Neural Tube Patterning Cell Projection Organization Embryonic Digit Morphogenesis Cilium Organization Roof Of Mouth Development Cilium Assembly Craniofacial Suture Morphogenesis Protein Localization To Ciliary Transition Zone Non-motile Cilium Assembly
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs		Enflurane Promethazine Miconazole Vernakalant Dalfampridine Isavuconazole
Diseases		Atrial fibrillation
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Longevity ( 30294719)	Diastolic blood pressure ( 30224653) Urinary potassium excretion ( 31409800)
Interacting Genes		11 interacting genes: ACTN2 DLG1 DLG4 ERBIN KCNA2 PTPRE SNTA1 SRC TMEM107 TNK2 UBE2I	45 interacting genes: AQP3 AQP6 BIK CCL21 CD40 CD79A CLN8 CLSTN3 CPLX4 EBAG9 ERGIC3 EVI2B FAM209A FAM210B FCER1G GJA5 GJA8 GPX8 KCNA5 KCNJ6 LHFPL5 LMNA MGST3 MS4A3 PDZK1IP1 PGRMC2 PIGP SAR1A SLC10A6 SLC30A2 SLC35H1 SLC39A2 SYT2 THAP4 TMEM106A TMEM139 TMEM167B TMEM234 TMEM237 TMEM31 TMEM51 TMEM52B TMEM80 TMEM86B VMA21
Entrez ID		3741	84314
HPRD ID		08888	14400
Ensembl ID		ENSG00000130037	ENSG00000179029
Uniprot IDs		P22460	E9PIH0 Q6UX40
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Cell Junction Anchoring Junction Neuromuscular Junction Glutamatergic Synapse Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Transport Juxtaparanode Region Of Axon Postsynaptic Density Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Angiotensin-activated Signaling Pathway Cell Adhesion Focal Adhesion Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Potassium Ion Transport Cellular Component Assembly Plasma Membrane Protein Localization To Postsynaptic Membrane Adherens Junction Protein Localization To Postsynapse Regulation Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transport Cell-substrate Junction Assembly Regulation Of Vesicle-mediated Transport Cell-substrate Junction Organization Regulation Of System Process Regulation Of Biological Quality Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Localization To Cell Periphery Receptor Localization To Synapse Regulation Of Cell Morphogenesis Receptor Clustering Regulation Of Blood Circulation Cell Junction Assembly Regulation Of Monoatomic Cation Transmembrane Transport Actin Filament Uncapping Protein Localization To Synapse P2Y1 Nucleotide Receptor Binding SUMO Conjugating Enzyme Activity Regulation Of Monoatomic Ion Transmembrane Transport Perinuclear Region Of Cytoplasm Epidermal Growth Factor Receptor Signaling Pathway Synaptic Membrane Regulation Of Multicellular Organismal Process Cytoskeletal Protein Binding Protein Localization To Membrane	Membrane Transmembrane Transport Protein Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Monoatomic Ion Transport Metal Ion Transport Renal Water Transport
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