PTPN14 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 12808048)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PTPN14	TJP1
Description		protein tyrosine phosphatase non-receptor type 14	tight junction protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction
	Molecular Function	Transcription Coregulator Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Receptor Tyrosine Kinase Binding	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Lymphangiogenesis Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Regulation Of Protein Export From Nucleus	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly
Pathways		Interleukin-37 signaling	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases		Choanal atresia and lymphedema
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Bone mineral density (hip) ( 30172743) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 25429064 28552196 31562340) Hip index ( 34021172) Lipid traits ( 24386095) Plasma thyroid-stimulating hormone levels ( 24722205)	Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)
Interacting Genes		7 interacting genes: CDH1 CTNNA2 CTNNB1 JUP TJP1 TRIP6 YWHAG	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3
Entrez ID		5784	7082
HPRD ID		04402	03002
Ensembl ID		ENSG00000152104	ENSG00000104067
Uniprot IDs		A8K6H6 Q15678	A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157
PDB IDs		2BZL 6IWD 6JJW	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Catenin Complex Cellular Response To Indole-3-methanol Response To Indole-3-methanol Anchoring Junction Cell Junction Organization Adherens Junction Cell Junction Assembly Cadherin Binding Cell-cell Junction Assembly Cell Adhesion Apical Junction Complex Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Adherens Junction Organization Desmosome Assembly Regulation Of Cell Adhesion Flotillin Complex Cell Adhesion Molecule Binding Alpha-catenin Binding Presynaptic Active Zone Cytoplasmic Component Regulation Of Cell Migration Focal Adhesion Regulation Of Cell Motility Desmosome Organization Regulation Of Locomotion Postsynaptic Density, Intracellular Component Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Lamellipodium Cell Junction Desmosome Basolateral Plasma Membrane Positive Regulation Of Protein Import Into Nucleus Synapse Organization Cell-cell Adhesion Mediated By Cadherin Response To Alcohol Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Intercalated Disc Regulation Of Anatomical Structure Morphogenesis Skin Development Intracellular Protein Localization Cellular Response To Oxygen-containing Compound Cell Migration Regulation Of Angiogenesis Regulation Of Protein Localization	Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?