PTPN14 and CTNNA2

Number of citations of the paper that reports this interaction (PMID 12808048)
19

Data Source:
HPRD (in vitro)

		PTPN14	CTNNA2
Gene Name		protein tyrosine phosphatase, non-receptor type 14	catenin (cadherin-associated protein), alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton	Cytoplasm Cytosol Adherens Junction Cell-cell Adherens Junction Actin Cytoskeleton Basolateral Plasma Membrane Lamellipodium Axon
	Molecular Function	Transcription Cofactor Activity Protein Tyrosine Phosphatase Activity Protein Binding Receptor Tyrosine Kinase Binding	Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Lymphangiogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Dephosphorylation Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Export From Nucleus	Axonogenesis Single Organismal Cell-cell Adhesion Radial Glia Guided Migration Of Purkinje Cell Muscle Cell Differentiation Dendrite Morphogenesis Brain Morphogenesis Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Structural Plasticity Prepulse Inhibition
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		6 interactors: CDH1 CTNNA2 CTNNB1 JUP TJP1 YWHAG	2 interactors: CTNNBIP1 PTPN14
Entrez ID		5784	1496
HPRD ID		04402	00228
Ensembl ID		ENSG00000152104	ENSG00000066032
Uniprot IDs		A8K6H6 Q15678	P26232 Q49AD3
PDB IDs		2BZL
Enriched GO Terms of Interacting Partners?		Cellular Response To Indole-3-methanol Cell Junction Assembly Cell-cell Junction Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Adherens Junction Organization Cell-cell Junction Assembly Cellular Response To Organonitrogen Compound Single Organismal Cell-cell Adhesion Regulation Of Cell Differentiation Regulation Of Cell Fate Specification Regulation Of Protein Localization To Cell Surface Epithelial Cell Development Establishment Of Endothelial Barrier Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Intracellular Transport Response To Organonitrogen Compound Membrane Organization Regulation Of Cell Fate Commitment Epithelial Cell-cell Adhesion Apoptotic Process Regulation Of Wnt Signaling Pathway Blastocyst Formation Adherens Junction Assembly Endothelial Cell Development Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Epithelial Cell Morphogenesis Multicellular Organismal Development Response To Organic Substance Anatomical Structure Development Cell Adhesion Cellular Response To Organic Cyclic Compound Regulation Of Morphogenesis Of A Branching Structure Protein Oligomerization Regulation Of Intracellular Transport Endothelial Cell Differentiation Cellular Protein Localization Developmental Process Establishment Of Protein Localization To Plasma Membrane In Utero Embryonic Development Response To Drug Positive Regulation Of Muscle Cell Differentiation Endothelium Development Epithelial Cell Differentiation Organelle Organization	Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Monocyte Differentiation Negative Regulation Of Cell Proliferation Lymphangiogenesis Lymph Vessel Morphogenesis Regulation Of Monocyte Differentiation Regulation Of DNA-templated Transcription, Initiation Lymph Vessel Development Regulation Of Protein Export From Nucleus Regulation Of Vascular Permeability Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of DNA Binding Regulation Of Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Protein Binding Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Osteoblast Differentiation Acute Inflammatory Response Positive Regulation Of Myeloid Cell Differentiation Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of DNA Binding Positive Regulation Of Ossification Renal Tubule Development Negative Regulation Of Binding Regulation Of Smooth Muscle Cell Proliferation Kidney Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Stem Cell Proliferation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Anatomical Structure Morphogenesis Mesonephros Development Regulation Of Osteoblast Differentiation Negative Regulation Of Protein Complex Assembly Nephron Development Regulation Of Protein Binding Kidney Epithelium Development Peptidyl-tyrosine Dephosphorylation Regulation Of Myeloid Cell Differentiation
Tagcloud ?		aberrant activators cooperatively decipher effectors exerting fate great hippo kibra last1 lats1 mesenchymal morphogenesis mst pivotal ppxy profound regulations rescue rescues sequestration ste20 summary taz terminus upstream ww yap	adherens anoikis arid1a cdh1 clustered complexity driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa rnf43 road signatures top
Tagcloud (Difference) ?		aberrant activators cooperatively decipher effectors exerting fate great hippo kibra last1 lats1 mesenchymal morphogenesis mst pivotal ppxy profound regulations rescue rescues sequestration ste20 summary taz terminus upstream ww yap	adherens anoikis arid1a cdh1 clustered complexity driver escape gli3 guided highlights hotspots illustrate integrative junction landscape muc6 multidimensional mutational organoid personalized perturbations perturbed players rhoa rnf43 road signatures top
Tagcloud (Intersection) ?