SUGP1 and MIR1-1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SUGP1	MIR1-1
Description		SURP and G-patch domain containing 1	microRNA 1-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Extracellular Space RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RNA Processing MRNA Processing RNA Splicing	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 32853455) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting triglyceride levels ( 32603185) Hepatic lipid content in extreme obesity ( 25246029) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Non-HDL cholesterol levels ( 32902719) Nonalcoholic fatty liver disease ( 34841290) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 32888494) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061 23974872) Tea consumption ( 31046077) Triglyceride levels ( 32203549 32902719) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Type 2 diabetes ( 30054458)	Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)
Interacting Genes		8 interacting genes: CEBPA MIR1-1 MIRLET7G PUF60 SNRPA SNRPB2 TFIP11 U2AF2	89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		57794	406904
HPRD ID		10468
Ensembl ID		ENSG00000105705	ENSG00000199017
Uniprot IDs		Q8IWZ8
PDB IDs		8EJM 8GXL 8GXM
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing Spliceosomal Complex Spliceosomal SnRNP Complex Nucleic Acid Binding MRNA Metabolic Process U1 SnRNA Binding RNA Metabolic Process RNA Processing U1 SnRNP Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Reversible Differentiation Positive Regulation Of Mesoderm Formation Ribonucleoprotein Complex Response To Vitamin B2 C/EBP Complex Nuclear Speck Catalytic Step 2 Spliceosome Poly-pyrimidine Tract Binding Spliceosomal Complex Disassembly RISC Complex Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cardiac Conduction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing CHOP-C/EBP Complex U2-type Post-mRNA Release Spliceosomal Complex Phenotypic Switching Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Mesoderm Development Regulatory NcRNA-mediated Post-transcriptional Gene Silencing White Fat Cell Proliferation Regulation Of MRNA Processing Post-transcriptional Gene Silencing Cell Migration Involved In Vasculogenesis Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Hematopoietic Stem Cell Proliferation	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleoplasm Nucleus MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Cytoplasmic Stress Granule Spliceosomal Complex Regulation Of Translation MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of RNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Ligase Activity TRNA Aminoacylation Nucleolus MRNA Stabilization P-body Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Cytoplasmic Translation Regulation Of Metabolic Process
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