SUGP1 and PUF60

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SUGP1	PUF60
Description		SURP and G-patch domain containing 1	poly(U) binding splicing factor 60
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Nucleus Nucleoplasm Cell Junction Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	RNA Processing MRNA Processing RNA Splicing	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Processing Apoptotic Process RNA Splicing
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 32853455) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting triglyceride levels ( 32603185) Hepatic lipid content in extreme obesity ( 25246029) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Non-HDL cholesterol levels ( 32902719) Nonalcoholic fatty liver disease ( 34841290) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 32888494) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061 23974872) Tea consumption ( 31046077) Triglyceride levels ( 32203549 32902719) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Type 2 diabetes ( 30054458)
Interacting Genes		8 interacting genes: CEBPA MIR1-1 MIRLET7G PUF60 SNRPA SNRPB2 TFIP11 U2AF2	109 interacting genes: ARL8A BORCS5 CACNA1A CCNC CD101 CEBPA CHD3 CPEB2 DDIT4L DDX50 ERG ERP29 FBXO7 FHL2 FTHL17 FUBP1 H1-2 ID3 IQCN KHDC4 MED28 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I MREG MYCBP2 OGT PCBP1 PCBP3 PPP1R16A PTBP2 QRICH1 RAD23B RAP1GDS1 SAP30BP SDCBP SF1 SIAH1 SNRPA SNRPF SRSF11 SUGP1 TAF2 TH U2AF2 UBE2I UBTFL1 UPF2 VIM YWHAG ZG16
Entrez ID		57794	22827
HPRD ID		10468	18051
Ensembl ID		ENSG00000105705	ENSG00000179950
Uniprot IDs		Q8IWZ8	E9PL19 E9PQ56 H0YEM1 Q9UHX1
PDB IDs		8EJM 8GXL 8GXM	2DNY 2KXF 2KXH 2QFJ 3DXB 3UE2 3US5 3UWT 5KVY 5KW1 5KW6 5KWQ 6LUR 6SLO 7Q8A 7Z3X
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing Spliceosomal Complex Spliceosomal SnRNP Complex Nucleic Acid Binding MRNA Metabolic Process U1 SnRNA Binding RNA Metabolic Process RNA Processing U1 SnRNP Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Reversible Differentiation Positive Regulation Of Mesoderm Formation Ribonucleoprotein Complex Response To Vitamin B2 C/EBP Complex Nuclear Speck Catalytic Step 2 Spliceosome Poly-pyrimidine Tract Binding Spliceosomal Complex Disassembly RISC Complex Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cardiac Conduction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing CHOP-C/EBP Complex U2-type Post-mRNA Release Spliceosomal Complex Phenotypic Switching Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Mesoderm Development Regulatory NcRNA-mediated Post-transcriptional Gene Silencing White Fat Cell Proliferation Regulation Of MRNA Processing Post-transcriptional Gene Silencing Cell Migration Involved In Vasculogenesis Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Hematopoietic Stem Cell Proliferation	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis MRNA Destabilization Negative Regulation Of Vasculature Development RNA Destabilization Regulation Of Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Locomotion Extracellular Space Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility
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