SUGP1 and MIRLET7G

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SUGP1	MIRLET7G
Description		SURP and G-patch domain containing 1	microRNA let-7g
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Extracellular Space RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	RNA Processing MRNA Processing RNA Splicing	Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Glucose Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cirrhosis (alcohol related) ( 32853455) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting triglyceride levels ( 32603185) Hepatic lipid content in extreme obesity ( 25246029) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Non-HDL cholesterol levels ( 32902719) Nonalcoholic fatty liver disease ( 34841290) Nonalcoholic steatohepatitis ( 32298765) Platelet count ( 32888494) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061 23974872) Tea consumption ( 31046077) Triglyceride levels ( 32203549 32902719) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 23974872)
Interacting Genes		8 interacting genes: CEBPA MIR1-1 MIRLET7G PUF60 SNRPA SNRPB2 TFIP11 U2AF2	116 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RBM4B RBM5 RBM6 RBMS1 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR
Entrez ID		57794	406890
HPRD ID		10468
Ensembl ID		ENSG00000105705	ENSG00000199150
Uniprot IDs		Q8IWZ8
PDB IDs		8EJM 8GXL 8GXM
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing Spliceosomal Complex Spliceosomal SnRNP Complex Nucleic Acid Binding MRNA Metabolic Process U1 SnRNA Binding RNA Metabolic Process RNA Processing U1 SnRNP Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Reversible Differentiation Positive Regulation Of Mesoderm Formation Ribonucleoprotein Complex Response To Vitamin B2 C/EBP Complex Nuclear Speck Catalytic Step 2 Spliceosome Poly-pyrimidine Tract Binding Spliceosomal Complex Disassembly RISC Complex Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cardiac Conduction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing CHOP-C/EBP Complex U2-type Post-mRNA Release Spliceosomal Complex Phenotypic Switching Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Mesoderm Development Regulatory NcRNA-mediated Post-transcriptional Gene Silencing White Fat Cell Proliferation Regulation Of MRNA Processing Post-transcriptional Gene Silencing Cell Migration Involved In Vasculogenesis Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Hematopoietic Stem Cell Proliferation	RNA Binding RNA Processing Nucleic Acid Binding RNA Metabolic Process MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleus Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MRNA 3'-UTR Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of RNA Stability Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process U2 SnRNP RNA Stabilization MRNA Stabilization Negative Regulation Of Translation Regulation Of Metabolic Process MiRNA Processing Protein-RNA Complex Assembly TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity U2-type Prespliceosome Assembly Negative Regulation Of Macromolecule Metabolic Process
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