SUGP1

Name	SURP and G-patch domain containing 1
Structure
Interactors	8 interactors: CEBPA MIR1-1 MIRLET7G PUF60 SNRPA SNRPB2 TFIP11 U2AF2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing RNA Splicing
Pathways	mRNA Splicing - Major Pathway
GWAS	Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Bipolar II disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) Cirrhosis (alcohol related) ( 32853455 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting triglyceride levels ( 32603185 ) Hepatic lipid content in extreme obesity ( 25246029 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Non-HDL cholesterol levels ( 32902719 ) Nonalcoholic fatty liver disease ( 34841290 ) Nonalcoholic steatohepatitis ( 32298765 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Postprandial triglyceride levels ( 32603185 ) Refractive error ( 32231278 ) Schizophrenia ( 29483656 25056061 23974872 ) Tea consumption ( 31046077 ) Triglyceride levels ( 32203549 32902719 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Type 2 diabetes ( 30054458 )
Entrez ID	57794
HPRD ID	10468
Ensembl ID	ENSG00000105705
Uniprot IDs	Q8IWZ8
PDB IDs	8EJM 8GXL 8GXM
GO Terms Enriched among Interactors ?	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing Spliceosomal Complex Spliceosomal SnRNP Complex Nucleic Acid Binding MRNA Metabolic Process U1 SnRNA Binding RNA Metabolic Process RNA Processing U1 SnRNP Nucleic Acid Metabolic Process Protein-RNA Complex Assembly Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Reversible Differentiation Positive Regulation Of Mesoderm Formation Ribonucleoprotein Complex Response To Vitamin B2 C/EBP Complex Nuclear Speck Catalytic Step 2 Spliceosome Poly-pyrimidine Tract Binding Spliceosomal Complex Disassembly RISC Complex Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cardiac Conduction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing CHOP-C/EBP Complex U2-type Post-mRNA Release Spliceosomal Complex Phenotypic Switching Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Mesoderm Development Regulatory NcRNA-mediated Post-transcriptional Gene Silencing White Fat Cell Proliferation Regulation Of MRNA Processing Post-transcriptional Gene Silencing Cell Migration Involved In Vasculogenesis Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Hematopoietic Stem Cell Proliferation