MIR1-1 and KIN

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR1-1	KIN
Description		microRNA 1-1	Kin17 DNA and RNA binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Protein-containing Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation	DNA Replication DNA Repair DNA Recombination MRNA Processing DNA Damage Response
Pathways			Protein methylation
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Asthma ( 31959851) Mean reticulocyte volume ( 32888494)
Interacting Genes		89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A	2 interacting genes: MIR1-1 MIR363
Entrez ID		406904	22944
HPRD ID			03425
Ensembl ID		ENSG00000199017	ENSG00000151657
Uniprot IDs			O60870
PDB IDs			2CKK 2V1N 7ABH 7ABI 8I0P 9COJ
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleoplasm Nucleus MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Cytoplasmic Stress Granule Spliceosomal Complex Regulation Of Translation MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of RNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Ligase Activity TRNA Aminoacylation Nucleolus MRNA Stabilization P-body Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Cytoplasmic Translation Regulation Of Metabolic Process	Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Receptor Complex Interleukin-2 Binding Interleukin-2 Receptor Activity Regulatory NcRNA-mediated Gene Silencing Reversible Differentiation Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Phenotypic Switching Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Cardiac Conduction Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Mesoderm Formation Positive Regulation Of Mesoderm Development Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cell Migration Involved In Vasculogenesis Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Positive Regulation Of Sarcomere Organization Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Activation-induced Cell Death Of T Cells Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Mesoderm Development Activated T Cell Proliferation Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Cardiac Muscle Contraction Regulation Of Response To Drug Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Sarcomere Organization Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Interleukin-2-mediated Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of T Cell Tolerance Induction Positive Regulation Of Cell Fate Commitment Positive Regulation Of Myotube Differentiation Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Cardiocyte Differentiation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
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