MIR1-1 and LIN28A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR1-1	LIN28A
Description		microRNA 1-1	lin-28 RNA binding posttranscriptional regulator A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex	P-body Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Translation Initiation Factor Binding MiRNA Binding Metal Ion Binding Pre-miRNA Binding Protein-RNA Adaptor Activity Sequence-specific MRNA Binding
	Biological Process	Positive Regulation Of Cell Fate Commitment Positive Regulation Of Heart Rate Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Cell Migration MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Differentiation Negative Regulation Of Lipid Biosynthetic Process Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Positive Regulation Of Cardiac Muscle Contraction Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Reversible Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Conduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Positive Regulation Of Mesoderm Formation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Cell Differentiation	Germ Cell Development MiRNA Metabolic Process MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Translation Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Positive Regulation Of TOR Signaling Positive Regulation Of Neuron Differentiation Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Translation Stem Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MiRNA-mediated Gene Silencing Cellular Response To Glucose Stimulus Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Pre-miRNA Processing Positive Regulation Of Cytoplasmic Translation
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Appendicular lean mass ( 33097823) Caffeine consumption from tea ( 33287642) Glucose homeostasis traits ( 25524916) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		89 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KIN KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SART3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A	74 interacting genes: MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PTBP1 TRIM28 ZDHHC17 ZNF275
Entrez ID		406904	79727
HPRD ID			17278
Ensembl ID		ENSG00000199017	ENSG00000131914
Uniprot IDs			Q9H9Z2
PDB IDs			2CQF 2LI8 5UDZ 8OPS 8OPT 8OST
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleoplasm Nucleus MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Cytoplasmic Stress Granule Spliceosomal Complex Regulation Of Translation MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of RNA Stability Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Ligase Activity TRNA Aminoacylation Nucleolus MRNA Stabilization P-body Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Cytoplasmic Translation Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Signal Transduction
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