SFMBT2 and SLF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFMBT2	SLF2
Description		Scm like with four mbt domains 2	SMC5/6 complex localization factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Nuclear Body Nuclear Speck	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm PML Body Smc5-Smc6 Complex Site Of Double-strand Break
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Fasting blood insulin (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Femur bone mineral density x serum urate levels interaction ( 34046847) Monoclonal gammopathy of undetermined significance ( 30737484)	Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)
Interacting Genes		13 interacting genes: AKT1 CLK1 ESR1 L3MBTL3 LYPLA1 PHC1 RNF181 SCMH1 SCML1 SCML2 SIAH1 SLF2 TFAP4	7 interacting genes: CALM1 CBS OPTN PSMA1 SFMBT2 SMC6 TRIM14
Entrez ID		57713	55719
HPRD ID		18853	12581
Ensembl ID		ENSG00000198879	ENSG00000119906
Uniprot IDs		Q5VUG0	Q8IX21
PDB IDs		1WJR	7T5P
Enriched GO Terms of Interacting Partners?		Histone Binding Chromatin Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nitric-oxide Synthase Regulator Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity PcG Protein Complex Maternal Process Involved In Female Pregnancy 14-3-3 Protein Binding Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Lipid Negative Regulation Of Macroautophagy Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of TRNA Methylation Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Macromolecule Metabolic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of Aggrephagy Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Macromolecule Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Cellular Response To Hormone Stimulus Post-translational Protein Modification Mammalian Oogenesis Stage Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Autophagy TRNA (guanine-N7)-methylation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway	Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Nucleus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Negative Regulation Of Receptor Recycling Type 2 Mitophagy DNA Secondary Structure Binding Interchromatin Granule Chromosomal Region Sex Chromosome Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking DNA Protection Modified Amino Acid Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Proteasome Core Complex, Alpha-subunit Complex Positive Regulation Of Xenophagy Smc5-Smc6 Complex Regulation Of Nitric Oxide Mediated Signal Transduction Response To Folic Acid Golgi Ribbon Formation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process
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