SFMBT2 and TFAP4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SFMBT2	TFAP4
Name		Scm like with four mbt domains 2	transcription factor AP-4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Nuclear Body Nuclear Speck	Chromatin Nucleus Nucleoplasm Mitochondrion Transcription Repressor Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Cellular Response To Dexamethasone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition
GWAS		Asthma (childhood onset) ( 31036433 ) Fasting blood insulin (BMI interaction) ( 22581228 ) Femoral neck bone mineral density ( 32239398 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Monoclonal gammopathy of undetermined significance ( 30737484 )	Brain morphology (MOSTest) ( 32665545 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Lung function (FEV1/FVC) ( 26635082 ) Platelet count ( 32888494 ) Prostate-specific antigen levels ( 28139693 ) Serum alkaline phosphatase levels ( 33547301 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		13 interacting genes: AKT1 CLK1 ESR1 L3MBTL3 LYPLA1 PHC1 RNF181 SCMH1 SCML1 SCML2 SIAH1 SLF2 TFAP4	12 interacting genes: AJUBA EXOSC8 GOLGA2 INCA1 MCRS1 PDE9A PTPN3 SFMBT2 TEKT4 TRAF1 TRAF4 VMAC
Entrez ID		57713	7023
HPRD ID		18853	11795
Ensembl ID		ENSG00000198879	ENSG00000090447
Uniprot IDs		Q5VUG0	Q01664
PDB IDs		1WJR	Not available
GO Terms Enriched among Interactors		Histone Binding Chromatin Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nitric-oxide Synthase Regulator Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity PcG Protein Complex Maternal Process Involved In Female Pregnancy 14-3-3 Protein Binding Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Lipid Negative Regulation Of Macroautophagy Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of TRNA Methylation Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Macromolecule Metabolic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of Aggrephagy Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Macromolecule Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Cellular Response To Hormone Stimulus Post-translational Protein Modification Mammalian Oogenesis Stage Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Autophagy TRNA (guanine-N7)-methylation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway	Thioesterase Binding Cytoskeleton Tumor Necrosis Factor Receptor Binding