ZNF529 and MYL2

Number of citations: 72 (PubMedID 27107012)
Data Source: BioGRID (two hybrid)

		ZNF529	MYL2
Name		zinc finger protein 529	myosin light chain 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways		Generic Transcription Pathway	Striated Muscle Contraction
Diseases		None	Hypertrophic cardiomyopathy (HCM)
GWAS		Low density lipoprotein cholesterol levels ( 33339817 )	Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 ) Alcohol consumption (max-drinks) ( 29460428 ) Body mass index ( 24861553 ) Coffee consumption ( 29367735 ) Coronary heart disease ( 23364394 ) Drinking behavior ( 23364009 ) Gamma glutamyl transpeptidase ( 21909109 ) Glycemic traits ( 23575436 ) Gout ( 25646370 ) HDL cholesterol ( 21909109 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 30718733 ) Hypertension ( 32709000 ) Metabolic syndrome ( 25705158 ) Metabolic syndrome (multivariate analysis) ( 29632305 ) Neutrophil count ( 29403010 ) Serum uric acid levels ( 32514006 ) Urate levels ( 31578528 ) White blood cell count ( 29403010 )
Interacting Genes		2 interacting genes: MYL2 SRPK2	12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
Entrez ID		57711	4633
HPRD ID		15821	01181
Ensembl ID		ENSG00000186020	ENSG00000111245
Uniprot IDs		A0A0C4DFR4 Q6P280	A0A590UJU8 G3V1V8 P10916 Q6IB42
PDB IDs		Not available	5TBY 8ACT 8G4L
GO Terms Enriched among Interactors		Muscle Cell Fate Specification Positive Regulation Of The Force Of Heart Contraction Myosin Heavy Chain Binding Cardiac Myofibril Nuclear Speck Organization R-loop Processing A Band Cardiac Myofibril Assembly Heart Process Myofibril Assembly Heart Contraction Regulation Of The Force Of Heart Contraction Actin Monomer Binding Anatomical Structure Formation Involved In Morphogenesis 14-3-3 Protein Binding Nuclear Body Organization Positive Regulation Of Viral Genome Replication Structural Constituent Of Muscle Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Myosin Complex Myofibril Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Heart Morphogenesis Sarcomere Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Viral Process Post-embryonic Development Muscle Tissue Morphogenesis Positive Regulation Of Neuron Apoptotic Process Regulation Of Viral Genome Replication Negative Regulation Of Viral Process Striated Muscle Contraction Cell Fate Specification Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Nucleus Organization	Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy