ZBTB4 and CBFA2T3

Number of citations of the paper that reports this interaction (PMID 23251453)
1

Data Source:
BioGRID (two hybrid)

		ZBTB4	CBFA2T3
Gene Name		zinc finger and BTB domain containing 4	core-binding factor, runt domain, alpha subunit 2; translocated to, 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Golgi Membrane Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Protein Binding Methyl-CpG Binding Methyl-CpNpG Binding Protein Kinase Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Cell Proliferation Granulocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CBFA2T3 HIPK2	14 interactors: CBFA2T2 GMEB2 HDAC1 HDAC3 MATN2 PRKAR2A RUNX1 RUNX1T1 SEC24A TCF3 ZBTB33 ZBTB38 ZBTB4 ZNF652
Entrez ID		57659	863
HPRD ID		11693	04847
Ensembl ID		ENSG00000174282	ENSG00000129993
Uniprot IDs		B3KVD4 Q9P1Z0	O75081
PDB IDs
Enriched GO Terms of Interacting Partners?		Myeloid Cell Differentiation Voluntary Musculoskeletal Movement PML Body Organization Iris Morphogenesis Hemopoiesis Lens Induction In Camera-type Eye Immune System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Embryonic Retina Morphogenesis In Camera-type Eye Granulocyte Differentiation Modulation By Virus Of Host Morphology Or Physiology Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Retina Layer Formation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Lens Morphogenesis In Camera-type Eye Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of DNA Binding Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Embryonic Camera-type Eye Morphogenesis Negative Regulation Of BMP Signaling Pathway Musculoskeletal Movement Embryonic Eye Morphogenesis Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Peptidyl-threonine Phosphorylation Adult Walking Behavior Positive Regulation Of Macromolecule Biosynthetic Process Developmental Induction Positive Regulation Of Gene Expression Neural Retina Development Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Retina Morphogenesis In Camera-type Eye Embryonic Camera-type Eye Development Positive Regulation Of Protein Binding Regulation Of Transcription From RNA Polymerase II Promoter DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of BMP Signaling Pathway Regulation Of DNA Binding Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lens Development In Camera-type Eye Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels	Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Receptor Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Histone H3 Deacetylation Histone H3-K9 Modification Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Skin Development Response To Growth Factor Dendrite Regeneration Histone Deacetylation Protein Deacetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Circadian Regulation Of Gene Expression Positive Regulation Of Progesterone Secretion Cellular Metabolic Process
Tagcloud ?		106a 106b anticancer axis betulinic clusters colonization consisting disruption ezh2 interference inverse methyltransferase mir mirs network oncogenic paralogues prediction publically reciprocally repressor sets signature sp sp1 sp3 sp4 turn	7q amotl1 cn crebbp cul1 directory exome expanding expands fat4 fbxo11 flnc ighv1 integrating map3k14 minimally mll2 notch2 pla2g4d positioned recurrently silent smzl spen splenic tnfaip3 trrap ush2a wes
Tagcloud (Difference) ?		106a 106b anticancer axis betulinic clusters colonization consisting disruption ezh2 interference inverse methyltransferase mir mirs network oncogenic paralogues prediction publically reciprocally repressor sets signature sp sp1 sp3 sp4 turn	7q amotl1 cn crebbp cul1 directory exome expanding expands fat4 fbxo11 flnc ighv1 integrating map3k14 minimally mll2 notch2 pla2g4d positioned recurrently silent smzl spen splenic tnfaip3 trrap ush2a wes
Tagcloud (Intersection) ?