LRFN1 and RGS2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)

		LRFN1	RGS2
Gene Name		leucine rich repeat and fibronectin type III domain containing 1	regulator of G-protein signaling 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Postsynaptic Density Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function		GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process		Regulation Of Translation Cell Cycle Spermatogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Smooth Muscle Positive Regulation Of Cardiac Muscle Contraction Regulation Of Adrenergic Receptor Signaling Pathway
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DLG4 RGS2	58 interactors: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CHD3 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KIAA1377 KLK8 LIG1 LRFN1 METTL18 MON1A MTUS2 NINL NIPSNAP1 PARK2 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		57622	5997
HPRD ID		19353	02917
Ensembl ID		ENSG00000128011	ENSG00000116741
Uniprot IDs		Q9P244	P41220
PDB IDs			2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Regulation Of Adrenergic Receptor Signaling Pathway Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cardiac Muscle Contraction Receptor Localization To Synapse Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Negative Regulation Of Receptor Internalization Relaxation Of Vascular Smooth Muscle Locomotory Exploration Behavior Negative Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Smooth Muscle Negative Regulation Of Muscle Hypertrophy Dendritic Spine Morphogenesis Positive Regulation Of Striated Muscle Contraction Maintenance Of Cell Polarity Synaptic Vesicle Maturation Positive Regulation Of GTPase Activity Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Regulation Of GTPase Activity Vocalization Behavior Negative Regulation Of Smooth Muscle Contraction Dendritic Spine Development Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Positive Regulation Of Hydrolase Activity Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Cortical Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Excitatory Postsynaptic Membrane Potential Vasodilation Golgi To Plasma Membrane Transport Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Social Behavior	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Platelet Activation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Wounding Blood Coagulation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Hemostasis Wound Healing Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Nervous System Development Regulation Of Cyclase Activity Activation Of Adenylate Cyclase Activity Signaling Response To Stress Neurotrophin Signaling Pathway Cell Communication Regulation Of Phosphorylation Dopamine Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Developmental Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Stimulus Regulation Of Muscle Contraction Anatomical Structure Development Regulation Of CAMP Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Hydrolase Activity Cell Activation Membrane Organization Regulation Of CAMP Metabolic Process Regulation Of Protein Phosphorylation System Development Positive Regulation Of Lyase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Budding Adrenergic Receptor Signaling Pathway
Tagcloud ?			3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Difference) ?			3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Intersection) ?