KDM3A and ETV2

Number of citations of the paper that reports this interaction (PMID 16619273)
14

Data Source:
BioGRID (pull down)

		KDM3A	ETV2
Gene Name		lysine (K)-specific demethylase 3A	ets variant 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Iron Ion Binding Androgen Receptor Binding Dioxygenase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Chromatin Organization Transcription, DNA-templated Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Androgen Receptor Signaling Pathway Histone H3-K9 Demethylation Histone H3-K9 Dimethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Formaldehyde Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Oxidation-reduction Process	Blastocyst Development Placenta Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Wnt Signaling Pathway Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Morphogenesis BMP Signaling Pathway Involved In Mesodermal Cell Fate Specification Positive Regulation Of Mesoderm Development
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ETV2 HIST2H3C MKL1 MKL2 MYOCD RIPK2	1 interactors: KDM3A
Entrez ID		55818	2116
HPRD ID		11054	16871
Ensembl ID		ENSG00000115548	ENSG00000105672
Uniprot IDs		Q9Y4C1	A6NFN5 B3KUL0 K7ERX2 O00321 Q3KNT2
PDB IDs
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Muscle Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Blood Vessel Morphogenesis Muscle Structure Development Blood Vessel Development Vasculature Development Hepatic Stellate Cell Activation BMP Signaling Pathway Involved In Mesodermal Cell Fate Specification Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Striated Muscle Tissue Development Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Negative Regulation Of Beta-amyloid Clearance Response To Interleukin-18 Positive Regulation Of Cell Differentiation Cardiovascular System Development Cardiac Muscle Tissue Development Negative Regulation Of Skeletal Muscle Cell Differentiation Fibroblast Activation Regulation Of Cell Growth By Extracellular Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Mesoderm Development Urinary Bladder Development Positive Regulation Of Smooth Muscle Cell Differentiation Response To Interleukin-12 Negative Regulation Of Cell Death RNA Biosynthetic Process	Formaldehyde Biosynthetic Process Histone H3-K9 Dimethylation Histone H3-K9 Demethylation Spermatid Nucleus Elongation Peptidyl-lysine Dimethylation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Histone Methylation Histone H3-K9 Methylation Spermatid Nucleus Differentiation Histone H3-K9 Modification Histone Lysine Demethylation Histone Demethylation Protein Demethylation Androgen Receptor Signaling Pathway Regulation Of Histone Methylation Demethylation Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Aldehyde Metabolic Process Negative Regulation Of Chromosome Organization Histone Lysine Methylation Peptidyl-lysine Methylation Nucleus Organization Histone Methylation Regulation Of Histone Modification Spermatid Development Hormone-mediated Signaling Pathway Spermatid Differentiation Protein Methylation Intracellular Receptor Signaling Pathway Regulation Of Chromosome Organization Germ Cell Development Peptidyl-lysine Modification
Tagcloud ?		1alpha 2alpha 6b catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm4b kdm4c kdm6b lysine mesylate mimic modestly o2 rnai tri	attempts balb converts creation ec ecs egfl7 elicits erg ets etvecs fli1 foxc2 hind matrigel nonvascular nu plexus plugs pluripotent regenerated specialize tal1 transduced transplanted undefined vasculature von willebrand
Tagcloud (Difference) ?		1alpha 2alpha 6b catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm4b kdm4c kdm6b lysine mesylate mimic modestly o2 rnai tri	attempts balb converts creation ec ecs egfl7 elicits erg ets etvecs fli1 foxc2 hind matrigel nonvascular nu plexus plugs pluripotent regenerated specialize tal1 transduced transplanted undefined vasculature von willebrand
Tagcloud (Intersection) ?