KDM3A and ETV2

Number of citations: 0 (PubMedID 16619273)
Data Source: BioGRID (pull down)

		KDM3A	ETV2
Name		lysine demethylase 3A	ETS variant transcription factor 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Dioxygenase Activity Histone H3K9me/H3K9me2 Demethylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Spermatogenesis Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Regulation Of Gene Expression Cell Differentiation Androgen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Formaldehyde Biosynthetic Process Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation	In Utero Embryonic Development Mesoderm Formation Blastocyst Development Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Positive Regulation Of Gene Expression Wnt Signaling Pathway Hemopoiesis Cell Differentiation Erythrocyte Differentiation BMP Signaling Pathway Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Mesoderm Development
Pathways		HDMs demethylate histones NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	None
GWAS		Atrial fibrillation ( 29892015 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Ovarian cancer ( 30557369 )	Brain morphology (MOSTest) ( 32665545 )
Interacting Genes		7 interacting genes: BTG3 ETV2 H3C14 MRTFA MRTFB MYOCD RIPK2	1 interacting genes: KDM3A
Entrez ID		55818	2116
HPRD ID		11054	16871
Ensembl ID		ENSG00000115548	ENSG00000105672
Uniprot IDs		Q9Y4C1	K7ERX2 O00321 Q3KNT2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Mesoderm Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Interleukin-18 Regulation Of Cell Growth By Extracellular Stimulus Positive Regulation Of Biosynthetic Process Response To Interleukin-12 Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Urinary Bladder Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Mesoderm Development Positive Regulation Of T-helper 1 Cell Differentiation Toll-like Receptor 2 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway LIM Domain Binding Cellular Response To Peptidoglycan Immature T Cell Proliferation In Thymus Xenophagy Positive Regulation Of Immature T Cell Proliferation In Thymus Protein Linear Polyubiquitination Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation Cardiac Ventricle Development Ductus Arteriosus Closure Regulation Of Phenotypic Switching Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Xenophagy Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Histone H3K9me/H3K9me2 Demethylase Activity Formaldehyde Biosynthetic Process Spermatid Nucleus Elongation Histone H3K9 Demethylase Activity Androgen Receptor Signaling Pathway Nuclear Androgen Receptor Binding Histone Deacetylase Complex Cellular Response To Leukemia Inhibitory Factor Dioxygenase Activity Regulation Of Stem Cell Differentiation Regulation Of Stem Cell Population Maintenance Chromatin DNA Binding Nuclear Receptor-mediated Signaling Pathway Nucleus Organization Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Leukemia Inhibitory Factor Aldehyde Metabolic Process Male Germ Cell Nucleus Positive Regulation Of Cold-induced Thermogenesis Iron Ion Binding Transcription Coregulator Activity Regulation Of Cold-induced Thermogenesis Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway