CCDC191 and TIGIT

Data Source: HiPPIP (Novel)

		CCDC191	TIGIT
Name		coiled-coil domain containing 191	T cell immunoreceptor with Ig and ITIM domains
Structure		No pdb structure
GO Annotations	Cellular Component	None	Plasma Membrane Cell Surface Membrane
	Molecular Function	None	Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	None	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Activation
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: TIGIT	5 novel interactors: B4GALT4 CCDC191 GRAMD1C QTRT2 ZDHHC23
Interacting Genes		None recorded	6 interacting genes: MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR
Entrez ID		57577	201633
HPRD ID		13856	08804
Ensembl ID		ENSG00000163617	ENSG00000181847
Uniprot IDs		Q8NCU4	Q495A1
PDB IDs		Not available	3Q0H 3RQ3 3UCR 3UDW 5V52 7VYT 8JEL 8JEN 8JEO 8SZY
GO Terms Enriched among Interactors		Positive Regulation Of Interleukin-10 Production Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Regulation Of Interleukin-12 Production Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Cytotoxicity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Negative Regulation Of T Cell Activation Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Immune Response Cell Killing Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Cell Activation Signaling Receptor Activity	Cell Adhesion Mediator Activity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Structural Constituent Of Myelin Sheath Virus Receptor Activity Cell Adhesion Molecule Binding Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Receptor Ligand Activity Positive Regulation Of Immune Response To Tumor Cell Cell-cell Contact Zone Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Cell-cell Adhesion Adherens Junction Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Establishment Of Protein Localization To Membrane Negative Regulation Of Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Negative Regulation Of Defense Response Membrane Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Sperm Mitochondrion Organization Lactosylceramide Biosynthetic Process Regulation Of Transcytosis TRNA-guanosine(34) Queuine Transglycosylase Activity TRNA Wobble Guanine Modification TRNA-guanine Transglycosylase Complex