MTUS1 and ORC4

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MTUS1	ORC4
Name		microtubule associated scaffold protein 1	origin recognition complex subunit 4
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Golgi Apparatus Centrosome Spindle Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Binding Microtubule Binding	Nucleotide Binding DNA Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Regulation Of Macrophage Chemotaxis	DNA Replication DNA Replication Initiation Polar Body Extrusion After Meiotic Divisions Protein Polymerization
Pathways		None	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Diseases		None	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Hippocampal volume in normal cognition ( 29274321 ) PR interval ( 32439900 )	Estimated glomerular filtration rate ( 30604766 31015462 31152163 ) Loneliness (MTAG) ( 29970889 ) Serum uric acid levels ( 30993211 ) Urate levels ( 31578528 )
Interacting Genes		7 interacting genes: AGTR2 FBXO7 FOXP1 ORC4 SKP1 STX5 STX7	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4C16 KLHL20 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RRM2B TCF4
Entrez ID		57509	5000
HPRD ID		11376	09118
Ensembl ID		ENSG00000129422	ENSG00000115947
Uniprot IDs		Q9ULD2	A8K7H4 O43929 Q96B14
PDB IDs		Not available	5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
GO Terms Enriched among Interactors		Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Morphogenesis Of An Epithelium SCF Ubiquitin Ligase Complex SNARE Binding SNARE Complex Vesicle Docking SNAP Receptor Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Metanephros Size Brain Renin-angiotensin System Ubiquitin-like Ligase-substrate Adaptor Activity Vesicle Fusion Organelle Localization By Membrane Tethering Membrane Docking Positive Regulation Of Interleukin-21 Production Organelle Membrane Fusion Protein K48-linked Ubiquitination Positive Regulation Of Metanephric Glomerulus Development F-box Domain Binding Tertiary Granule Lewy Body Core Organelle Fusion Positive Regulation Of Programmed Cell Death Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Angiotensin Type II Receptor Activity Cul7-RING Ubiquitin Ligase Complex Positive Regulation Of Receptor Localization To Synapse Negative Regulation Of Cell Growth Regulation Of Apoptotic Process Positive Regulation Of Glomerulus Development Regulation Of Kidney Size Regulation Of Blood Volume By Renin-angiotensin Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Membrane Fusion Golgi Disassembly Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Programmed Cell Death Vesicle Chloride Channel Inhibitor Activity Osteoclast Development Regulation Of Endothelial Tube Morphogenesis Regulation Of Endothelial Cell Migration Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure	DNA Replication Initiation DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Origin Recognition Complex DNA Replication Origin Binding DNA Metabolic Process CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Single-stranded DNA Binding Regulation Of DNA Replication Nucleus Mitotic DNA Replication Initiation Single-stranded DNA Helicase Activity Regulation Of DNA Metabolic Process Chromosome Nucleic Acid Metabolic Process DNA Damage Response DNA Helicase Activity Nucleoplasm DNA Repair DNA Binding Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Recombination Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Recombinational Repair DNA Strand Elongation Cellular Response To Stress DNA-templated DNA Replication SCF Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Mammary Gland Epithelial Cell Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Enzyme Binding Nucleolus Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Cell Population Proliferation Regulation Of Cell Cycle G2/M Phase Transition Amyloid Fibril Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle