MTUS1 and ORC4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MTUS1	ORC4
Gene Name		microtubule associated tumor suppressor 1	origin recognition complex, subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Microtubule Plasma Membrane	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Actin Cytoskeleton
	Molecular Function		Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Regulation Of Macrophage Chemotaxis Cellular Response To Peptide Hormone Stimulus	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways			G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: AGTR2 ORC4	27 interactors: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 HIST3H3 HIST4H4 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RPA2 RRM2B TCF4
Entrez ID		57509	5000
HPRD ID		11376	09118
Ensembl ID		ENSG00000129422	ENSG00000115947
Uniprot IDs		Q9ULD2	A8K7H4 O43929 Q96B14
PDB IDs
Enriched GO Terms of Interacting Partners?		Aldosterone Secretion Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Metanephros Size G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Negative Regulation Of Icosanoid Secretion Regulation Of Kidney Size Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Metanephric Glomerulus Development Regulation Of Blood Vessel Size By Renin-angiotensin Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Angiotensin-activated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Brain Renin-angiotensin System Positive Regulation Of Glomerulus Development Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Heart Rate Positive Regulation Of Renal Sodium Excretion Dopamine Biosynthetic Process Cellular Sodium Ion Homeostasis Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Norepinephrine Secretion Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Nitric Oxide Mediated Signal Transduction Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Blood Vessel Endothelial Cell Migration Catecholamine Biosynthetic Process Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Renal Sodium Excretion Negative Regulation Of Heart Contraction Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Lipid Transport Sodium Ion Homeostasis Positive Regulation Of Monooxygenase Activity Regulation Of Excretion Cardiac Muscle Hypertrophy Negative Regulation Of Receptor Activity Muscle Hypertrophy Exploration Behavior Dopamine Metabolic Process Positive Regulation Of Phosphatase Activity Cellular Response To Dexamethasone Stimulus Positive Regulation Of Vasodilation Regulation Of Fatty Acid Transport Metanephros Morphogenesis	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication DNA Replication DNA Replication Initiation Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process Chromosome Organization DNA Unwinding Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process DNA Conformation Change DNA Duplex Unwinding DNA Geometric Change Biosynthetic Process Organelle Organization Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Regulation Of DNA Recombination Telomere Maintenance Regulation Of Mitotic Cell Cycle Phase Transition Cell Proliferation Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Cell Cycle Chromatin Assembly Cellular Process Cellular Macromolecular Complex Assembly Response To Epidermal Growth Factor Regulation Of Protein Export From Nucleus Chromatin Assembly Or Disassembly
Tagcloud ?		applicability csmd1 cttn delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Difference) ?		applicability csmd1 cttn delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Intersection) ?