MTUS1 and AGTR2

Number of citations of the paper that reports this interaction (PMID 15123706)
21

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MTUS1	AGTR2
Gene Name		microtubule associated tumor suppressor 1	angiotensin II receptor, type 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Mitochondrion Golgi Apparatus Microtubule Organizing Center Spindle Microtubule Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function		Angiotensin Type II Receptor Activity Protein Binding Transcription Factor Binding Peptide Hormone Binding Receptor Antagonist Activity
	Biological Process	Regulation Of Macrophage Chemotaxis Cellular Response To Peptide Hormone Stimulus	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Cellular Sodium Ion Homeostasis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Nitric Oxide Mediated Signal Transduction Brain Development Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Negative Regulation Of Heart Rate Negative Regulation Of Norepinephrine Secretion Cerebellar Cortex Development Negative Regulation Of Cell Growth Negative Regulation Of Icosanoid Secretion Positive Regulation Of Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Regulation Of Metanephros Size Exploration Behavior Positive Regulation Of Renal Sodium Excretion Aldosterone Secretion Angiotensin-activated Signaling Pathway Dopamine Biosynthetic Process Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cytokine Secretion Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Dexamethasone Stimulus Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Cystic fibrosis severity ( 21602797)
Protein-Protein Interactions		2 interactors: AGTR2 ORC4	11 interactors: ACE AGT AGTRAP ERBB2IP ERBB3 GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		57509	186
HPRD ID		11376	02071
Ensembl ID		ENSG00000129422	ENSG00000180772
Uniprot IDs		Q9ULD2	P50052
PDB IDs
Enriched GO Terms of Interacting Partners?		Aldosterone Secretion Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Metanephros Size G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Negative Regulation Of Icosanoid Secretion Regulation Of Kidney Size Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Metanephric Glomerulus Development Regulation Of Blood Vessel Size By Renin-angiotensin Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Angiotensin-activated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Brain Renin-angiotensin System Positive Regulation Of Glomerulus Development Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Heart Rate Positive Regulation Of Renal Sodium Excretion Dopamine Biosynthetic Process Cellular Sodium Ion Homeostasis Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Norepinephrine Secretion Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Nitric Oxide Mediated Signal Transduction Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extracellular Negative Regulation Of Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Blood Vessel Endothelial Cell Migration Catecholamine Biosynthetic Process Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Renal Sodium Excretion Negative Regulation Of Heart Contraction Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Lipid Transport Sodium Ion Homeostasis Positive Regulation Of Monooxygenase Activity Regulation Of Excretion Cardiac Muscle Hypertrophy Negative Regulation Of Receptor Activity Muscle Hypertrophy Exploration Behavior Dopamine Metabolic Process Positive Regulation Of Phosphatase Activity Cellular Response To Dexamethasone Stimulus Positive Regulation Of Vasodilation Regulation Of Fatty Acid Transport Metanephros Morphogenesis	Regulation Of Renal Output By Angiotensin Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Vasoconstriction Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Angiotensin Maturation Regulation Of Protein Kinase Activity Regulation Of Angiotensin Metabolic Process Regulation Of Blood Volume By Renin-angiotensin Regulation Of Kinase Activity Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Phosphorylation Cell Division Positive Regulation Of Protein Modification Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Adenylate Cyclase Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Lyase Activity Phosphatidylinositol 3-kinase Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Blood Pressure Regulation Of Protein Phosphorylation Negative Regulation Of CAMP Biosynthetic Process Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Wound Healing Peptide Hormone Processing Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Regulation Of Immune System Process Regulation Of Phosphorylation Cell Activation Regulation Of Protein Metabolic Process Blood Vessel Remodeling Regulation Of Cellular Component Movement Regulation Of Vasodilation
Tagcloud ?		applicability csmd1 cttn delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	ace acquired acquisition adjuvant agtr1 angiotensin blockers captopril continuously converting endocrine expressions innate losartan mcf mtt mumol phenotype prevention preventive problem qrt ras renin resistant reversion tam tamoxifen viability
Tagcloud (Difference) ?		applicability csmd1 cttn delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	ace acquired acquisition adjuvant agtr1 angiotensin blockers captopril continuously converting endocrine expressions innate losartan mcf mtt mumol phenotype prevention preventive problem qrt ras renin resistant reversion tam tamoxifen viability
Tagcloud (Intersection) ?