MTUS1 and AGTR2

Number of citations of the paper that reports this interaction (PubMedID 15123706)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MTUS1	AGTR2
Description		microtubule associated scaffold protein 1	angiotensin II receptor type 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Golgi Apparatus Centrosome Spindle Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Microtubule Binding	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity
	Biological Process	Regulation Of Macrophage Chemotaxis	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Brain Development Regulation Of Blood Pressure Negative Regulation Of Heart Rate Negative Regulation Of Cell Growth Regulation Of Metanephros Size Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Vasodilation Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Blood Vessel Diameter Maintenance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Tasosartan CYT006-AngQb Olodanrigan
Diseases			Non-syndromic X-linked mental retardation
GWAS		Hippocampal volume in normal cognition ( 29274321) PR interval ( 32439900)	Cystic fibrosis severity ( 21602797) Gestational age at birth (maternal effect) ( 28877031) Lung disease severity in cystic fibrosis ( 26417704) Offspring birth weight ( 31043758) Preterm birth (maternal effect) ( 28877031) Type 2 diabetes ( 29358691 30130595)
Interacting Genes		7 interacting genes: AGTR2 FBXO7 FOXP1 ORC4 SKP1 STX5 STX7	13 interacting genes: ACE ACE2 AGT AGTRAP ARRB2 ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		57509	186
HPRD ID		11376	02071
Ensembl ID		ENSG00000129422	ENSG00000180772
Uniprot IDs		Q9ULD2	P50052
PDB IDs			5UNF 5UNG 5UNH 5XJM 6JOD 7C6A 7JNI
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Morphogenesis Of An Epithelium SCF Ubiquitin Ligase Complex SNARE Binding SNARE Complex Vesicle Docking SNAP Receptor Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Metanephros Size Brain Renin-angiotensin System Ubiquitin-like Ligase-substrate Adaptor Activity Vesicle Fusion Organelle Localization By Membrane Tethering Membrane Docking Positive Regulation Of Interleukin-21 Production Organelle Membrane Fusion Protein K48-linked Ubiquitination Positive Regulation Of Metanephric Glomerulus Development F-box Domain Binding Tertiary Granule Lewy Body Core Organelle Fusion Positive Regulation Of Programmed Cell Death Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Angiotensin Type II Receptor Activity Cul7-RING Ubiquitin Ligase Complex Positive Regulation Of Receptor Localization To Synapse Negative Regulation Of Cell Growth Regulation Of Apoptotic Process Positive Regulation Of Glomerulus Development Regulation Of Kidney Size Regulation Of Blood Volume By Renin-angiotensin Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Membrane Fusion Golgi Disassembly Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Programmed Cell Death Vesicle Chloride Channel Inhibitor Activity Osteoclast Development Regulation Of Endothelial Tube Morphogenesis Regulation Of Endothelial Cell Migration Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Angiotensin-activated Signaling Pathway Type 2 Angiotensin Receptor Binding Peptidyl-dipeptidase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Renal Output By Angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Pressure Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Vasoconstriction Positive Regulation Of Reactive Oxygen Species Metabolic Process Plasma Membrane G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signal Transduction Regulation Of Blood Circulation Angiotensin Maturation Regulation Of System Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Guanyl Nucleotide Binding Renal System Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation G-protein Beta/gamma-subunit Complex Binding Regulation Of Reactive Oxygen Species Metabolic Process Metallocarboxypeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Regulation Of Superoxide Metabolic Process Negative Regulation Of Catalytic Activity Carboxypeptidase Activity Negative Regulation Of MAPK Cascade Kidney Development Regulation Of Intracellular Signal Transduction Sodium Channel Regulator Activity
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