MTA3 and BCAR3

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		MTA3	BCAR3
Name		metastasis associated 1 family member 3	BCAR3 adaptor protein, NSP family member
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm NuRD Complex	Cytoplasm Focal Adhesion Membrane Anchoring Junction
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Stem Cell Differentiation	Lens Morphogenesis In Camera-type Eye Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Endothelin Receptor Signaling Pathway
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	None
GWAS		Breastfeeding duration ( 25475840 )	Alzheimer's disease progression score ( 29860282 ) Blood urea nitrogen levels ( 31152163 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Estimated glomerular filtration rate ( 31152163 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Liver fibrosis (total hepatic collagen content) ( 32953199 ) Major depressive disorder ( 27777418 ) Systolic blood pressure ( 30224653 )
Interacting Genes		23 interacting genes: AKT1 ARNT ATM AURKA BAG4 BCAR3 BCL6 CDKN2C DSCAM DYRK1A ERCC6 FGFR2 FGFR4 FOXK2 FZR1 GRB2 IGF1R KDM1A NACC2 NOTCH2 PARP1 TGFB1 TSG101	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 DRC4 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		57504	8412
HPRD ID		12359	05268
Ensembl ID		ENSG00000057935	ENSG00000137936
Uniprot IDs		F6RRE2 Q9BTC8	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs		Not available	3T6A
GO Terms Enriched among Interactors		Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of DNA Recombination Response To Ionizing Radiation Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of DNA Metabolic Process Negative Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Signal Transduction Protein Phosphorylation Cellular Developmental Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Response To Gamma Radiation Positive Regulation Of Cellular Component Organization Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Organelle Organization Response To Radiation Positive Regulation Of Fibroblast Migration Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Cellular Response To Stress Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Tyrosine Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Response To Epidermal Growth Factor Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Epithelial Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Molecular Function Inhibitor Activity Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Protein Modification Process Protein Kinase Activity Positive Regulation Of Lymphocyte Migration Positive Chemotaxis ERBB2-EGFR Signaling Pathway Growth Factor Binding Regulation Of Primary Metabolic Process Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway