NLGN4X and CCL22

		NLGN4X	CCL22
Description		neuroligin 4 X-linked	C-C motif chemokine ligand 22
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Dendrite Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse Postsynaptic Specialization Membrane	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Chloride Ion Binding Neurexin Family Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Scaffold Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Brainstem Development Cell Adhesion Neuron Cell-cell Adhesion Learning Cerebellum Development Neuron Differentiation Adult Behavior Social Behavior Organ Growth Cell-cell Junction Organization Modulation Of Chemical Synaptic Transmission Synapse Organization Regulation Of Synapse Assembly Vocalization Behavior Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Presynapse Assembly	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Metabolite levels ( 23823483) Schizophrenia ( 25056061 29483656)	Asthma ( 32296059) Blood protein levels ( 30072576) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469 33272962)
Interacting Genes		2 interacting genes: DLG4 DLGAP2	10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1
Entrez ID		57502	6367
HPRD ID		02336	04263
Ensembl ID		ENSG00000146938	ENSG00000102962
Uniprot IDs		A8K4S1 B3KP11 Q8N0W4	O00626
PDB IDs		2WQZ 2XB6 3BE8
Enriched GO Terms of Interacting Partners?			Chemotaxis Locomotion Cell Chemotaxis Chemokine Activity Cell Migration Inflammatory Response Chemokine-mediated Signaling Pathway Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response Response To Stress Antimicrobial Humoral Response CCR Chemokine Receptor Binding Regulation Of Neutrophil Chemotaxis Cytokine Activity Regulation Of Neutrophil Migration T Cell Costimulation Nitrate Transmembrane Transporter Activity Immune System Process Cell Surface Positive Regulation Of T Cell Activation Regulation Of Granulocyte Chemotaxis Glucagon Processing Regulation Of Cell Activation Humoral Immune Response Positive Regulation Of Dendritic Cell Dendrite Assembly Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Hypoxia PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Extracellular Region Response To Lipid Response To Oxygen Levels Response To Decreased Oxygen Levels Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Cellular Response To Thyroxine Stimulus Negative Regulation Of Hepatic Stellate Cell Activation Glutamate-cysteine Ligase Activity Glutamate-cysteine Ligase Complex Granulocyte Chemotaxis CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Peripheral Nervous System Neuron Differentiation Response To Heat Granulocyte Migration Cell Adhesion Molecule Binding Regulation Of Leukocyte Cell-cell Adhesion
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