NLGN4X and DLGAP2

Number of citations of the paper that reports this interaction (PMID 11368788)
34

Data Source:
HPRD (in vitro)

		NLGN4X	DLGAP2
Gene Name		neuroligin 4, X-linked	discs, large (Drosophila) homolog-associated protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Integral Component Of Membrane Cell Junction Dendrite Synapse Postsynaptic Membrane Excitatory Synapse	Neurofilament Postsynaptic Density Cell Junction Postsynaptic Membrane
	Molecular Function	Receptor Activity Protein Binding Chloride Ion Binding Neurexin Family Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity	Protein Binding
	Biological Process	Brainstem Development Neuron Cell-cell Adhesion Learning Metabolic Process Cerebellum Development Neuron Differentiation Adult Behavior Social Behavior Organ Growth Cell-cell Junction Organization Regulation Of Synaptic Transmission Synapse Organization Vocalization Behavior Negative Regulation Of Excitatory Postsynaptic Membrane Potential Presynaptic Membrane Assembly	Neuron-neuron Synaptic Transmission
Pathways
Drugs
Diseases
GWAS			Menarche (age at onset) ( 23599027)
Protein-Protein Interactions		2 interactors: DLG4 DLGAP2	13 interactors: ADRB1 BZRAP1 DGCR6 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 NLGN4X NOS1 SHANK2 SHANK3 SORBS2
Entrez ID		57502	9228
HPRD ID		02336	09258
Ensembl ID		ENSG00000146938	ENSG00000198010
Uniprot IDs		A8K4S1 B3KP11 Q8N0W4	Q9P1A6
PDB IDs		2WQZ 2XB6 3BE8
Enriched GO Terms of Interacting Partners?		Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Negative Regulation Of Receptor Internalization Locomotory Exploration Behavior Dendritic Spine Morphogenesis Maintenance Of Cell Polarity Synaptic Vesicle Maturation Vocalization Behavior Dendritic Spine Development Protein Localization To Synapse Cell-cell Signaling Negative Regulation Of Receptor-mediated Endocytosis Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Golgi To Plasma Membrane Transport Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Social Behavior Positive Regulation Of Membrane Potential Negative Regulation Of Endocytosis Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Nucleotide Phosphorylation Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuromuscular Process Controlling Balance Synapse Assembly Dendrite Morphogenesis Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Neuromuscular Process Learning	Vocalization Behavior Social Behavior Regulation Of Postsynaptic Membrane Potential Synapse Assembly Learning Or Memory Synaptic Transmission Cognition Regulation Of Synaptic Transmission Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synapse Organization Single-organism Behavior Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Membrane Potential Positive Regulation Of Ion Transmembrane Transport Dendritic Spine Morphogenesis Positive Regulation Of Synaptic Transmission Membrane Depolarization Memory Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Regulation Of Synaptic Plasticity Adult Behavior Exploration Behavior Postsynaptic Membrane Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Ion Transport Regulation Of The Force Of Heart Contraction Neurological System Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signaling Regulation Of Ion Transport Positive Regulation Of Membrane Potential Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Receptor Clustering Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Transporter Activity Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity
Tagcloud ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn1 ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	bell bgh bio blots bromo cnp deoxyuridine dor fibrillary gfap gh glul glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Difference) ?		agt ass1 beadchip benjamini crym differentiates egr2 folr3 gja1 hochberg hrasls humanref illumina leiomyosarcoma lms lmss masp1 nlgn1 ostn rorb shmt1 slitrk4 tdo2 thbs1 tnnt1 tspan10 tspan7 uterine xrn2	bell bgh bio blots bromo cnp deoxyuridine dor fibrillary gfap gh glul glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Intersection) ?