PPP1R3F and AGTR1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		PPP1R3F	AGTR1
Name		protein phosphatase 1 regulatory subunit 3F	angiotensin II receptor type 1
Structure		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Phosphatase 1 Binding Protein Phosphatase Binding Glycogen Binding	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		None	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases		None	Renal tubular dysgenesis
GWAS		Asthma ( 30929738 ) Asthma (childhood onset) ( 30929738 )	Birth weight ( 31043758 ) Chin dimples ( 27182965 ) Height ( 31562340 ) Lead levels in blood ( 25820613 ) Monobrow ( 27182965 ) Type 2 diabetes ( 31049640 )
Novel Interactors		None recorded	1 novel interactors: ACADM
Interacting Genes		5 interacting genes: AGTR1 GPR35 HTR2B PTGER4 UBE3A	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		89801	185
HPRD ID		15170	00107
Ensembl ID		ENSG00000049769	ENSG00000144891
Uniprot IDs		Q0D2I0 Q6ZSY5	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		Not available	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell Proliferation Angiotensin Type I Receptor Activity Animal Organ Development Negative Regulation Of Eosinophil Extravasation Sperm Entry Positive Regulation Of Golgi Lumen Acidification Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Positive Regulation Of Lipid Metabolic Process Regulation Of Tube Size Intracellular Signal Transduction Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Regulation Of Endothelial Cell Proliferation Renin-angiotensin Regulation Of Aldosterone Production Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Golgi Lumen Acidification Calcium-mediated Signaling Signal Transduction Intracellular Signaling Cassette Angiotensin Type II Receptor Activity Positive Regulation Of Inflammatory Response G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Prostaglandin Receptor Activity Positive Regulation Of Epithelial Cell Proliferation Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Prostaglandin E Receptor Activity Positive Regulation Of Cellular PH Reduction Response To Ketone Positive Regulation Of Protein Localization To Lysosome MAPK Cascade Vascular Process In Circulatory System Regulation Of Renal Sodium Excretion C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Negative Regulation Of Cellular Extravasation Serotonin Binding Serotonin Receptor Signaling Pathway Prostate Gland Growth Regulation Of Lipid Metabolic Process	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway