PTGFR and PTGES2

Number of citations of the paper that reports this interaction (PMID 8300593)
31

Data Source:
HPRD (in vivo)

		PTGFR	PTGES2
Gene Name		prostaglandin F receptor (FP)	prostaglandin E synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Nucleus Mitochondrion Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Prostaglandin F Receptor Activity	DNA Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Lyase Activity Heme Binding Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Parturition Positive Regulation Of Cell Proliferation Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Prostaglandin Biosynthetic Process Cell Redox Homeostasis Positive Regulation Of Transcription, DNA-templated Secretion Oxidation-reduction Process
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost Tromethamine Tafluprost
Diseases
GWAS		Bipolar disorder ( 22182935)
Protein-Protein Interactions		4 interactors: PTGDS PTGER1 PTGER2 PTGES2	4 interactors: C1orf189 CEBPB EXOSC10 PTGFR
Entrez ID		5737	80142
HPRD ID		08988	07458
Ensembl ID		ENSG00000122420	ENSG00000148334
Uniprot IDs		P43088	A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs
Enriched GO Terms of Interacting Partners?		Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Negative Regulation Of Eosinophil Extravasation Response To Lipid Fatty Acid Biosynthetic Process Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus Response To Bacterium Cyclooxygenase Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep ERK1 And ERK2 Cascade Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Negative Regulation Of Leukocyte Migration Response To Organic Substance T-helper Cell Differentiation Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Lipid Metabolic Process Alpha-beta T Cell Differentiation Carboxylic Acid Metabolic Process Regulation Of Stress Fiber Assembly Arachidonic Acid Metabolic Process Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Response To Fatty Acid Cellular Response To Mechanical Stimulus Organic Acid Metabolic Process G-protein Coupled Receptor Signaling Pathway JNK Cascade Positive Regulation Of Cytokine Secretion Lipid Metabolic Process Positive Regulation Of Inflammatory Response	Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Cellular Response To Acid Chemical Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Response To Bacterium Intracellular MRNA Localization Dosage Compensation RRNA Catabolic Process Calcium-mediated Signaling Using Intracellular Calcium Source Maturation Of 5.8S RRNA Parturition Cellular Response To Prostaglandin Stimulus Histone MRNA Metabolic Process Response To Other Organism Regulation Of Interleukin-6 Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Response To Biotic Stimulus Response To Lipid RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Acute-phase Response Negative Regulation Of Cell Death Brown Fat Cell Differentiation Cellular Response To Fatty Acid Positive Regulation Of Fat Cell Differentiation Cellular Response To Amino Acid Stimulus Reproductive Process Response To Fatty Acid Positive Regulation Of Osteoblast Differentiation Acute Inflammatory Response Regulation Of Apoptotic Process Epithelial Cell Proliferation Calcium-mediated Signaling Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Death Positive Regulation Of Ossification Mammary Gland Epithelium Development Regulation Of Interleukin-6 Production RNA Phosphodiester Bond Hydrolysis Regulation Of Cytokine Biosynthetic Process
Tagcloud ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?