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RPS6KA2
Gene Name
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Nuclear Membrane
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Oocyte Maturation
Brain Renin-angiotensin System
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Signal Transduction
Synaptic Transmission
Axon Guidance
Heart Development
Negative Regulation Of Cell Proliferation
Positive Regulation Of Gene Expression
Cardiac Muscle Cell Apoptotic Process
Peptidyl-serine Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Positive Regulation Of Apoptotic Process
Innate Immune Response
Negative Regulation Of Cell Cycle
Negative Regulation Of Meiotic Nuclear Division
Neurotrophin TRK Receptor Signaling Pathway
Stress-activated MAPK Cascade
Heart Contraction
Regulation Of Protein Processing
Cellular Response To Carbohydrate Stimulus
Pathways
Signaling by GPCR
CREB phosphorylation
Axon guidance
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
CREB phosphorylation
L1CAM interactions
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
RSK activation
Activation of NMDA receptor upon glutamate binding and postsynaptic events
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ERK/MAPK targets
Post NMDA receptor activation events
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Senescence-Associated Secretory Phenotype (SASP)
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
ERK/MAPK targets
Toll Like Receptor 3 (TLR3) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Transmission across Chemical Synapses
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Dental caries (
23259602
)
Inflammatory bowel disease (
23128233
)
Protein-protein Interactions
12 interactors:
BAD
CREB1
CSNK2B
FLNC
FOS
JUN
L1CAM
MAGI1
MAP2K1
MAPK1
MAPK3
SHANK1
Entrez ID
6196
HPRD ID
03403
Ensembl ID
ENSG00000071242
Uniprot IDs
F2Z2J1
Q15349
PDB IDs
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Fc Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Regulation Of Golgi Inheritance
Response To External Stimulus
MAPK Cascade
Immune Response-regulating Signaling Pathway
Innate Immune Response
Neuron Projection Development
Response To Organonitrogen Compound
Regulation Of Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Signal Transduction By Phosphorylation
Neuron Development
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Regulation Of Golgi Organization
Neuron Projection Morphogenesis
Neuron Differentiation
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cell Projection Organization
Response To Cytokine
Cell Morphogenesis Involved In Differentiation
Axon Guidance
Cell Development
Regulation Of Early Endosome To Late Endosome Transport
Cellular Response To Organic Substance
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