TMEM159 and GAD2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TMEM159	GAD2
Gene Name		transmembrane protein 159	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Golgi Membrane Cytosol Plasma Membrane Cell Junction Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function		Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein Heterodimerization Activity
	Biological Process		Glutamate Decarboxylation To Succinate Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug
Pathways			Neurotransmitter Release Cycle GABA synthesis GABA synthesis, release, reuptake and degradation Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ADCK3 CACFD1 GAD2 ZNF391	9 interactors: AGTRAP ARL6IP1 CMTM5 F10 GAD1 MAL2 PRKACA PRKCE TMEM159
Entrez ID		57146	2572
HPRD ID		17428	11817
Ensembl ID		ENSG00000011638	ENSG00000136750
Uniprot IDs		B4DEC1 Q96B96	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?		Glutamate Decarboxylation To Succinate Glutamate Catabolic Process Succinate Metabolic Process Dicarboxylic Acid Catabolic Process Neurotransmitter Biosynthetic Process Synaptic Transmission Ubiquinone Biosynthetic Process Glutamate Metabolic Process Ubiquinone Metabolic Process Neurotransmitter Metabolic Process Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Quinone Metabolic Process	Positive Regulation Of Cell Migration Activation Of Phospholipase C Activity Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Phospholipase C Activity Blood Coagulation Hemostasis Positive Regulation Of Phospholipase Activity Positive Regulation Of Epithelial Cell Migration Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cellular Glucuronidation Regulation Of Body Fluid Levels Regulation Of Cell Migration Peptidyl-serine Phosphorylation Wound Healing Glutamate Decarboxylation To Succinate TRAM-dependent Toll-like Receptor 4 Signaling Pathway Protein-pyridoxal-5-phosphate Linkage Histone H3-T6 Phosphorylation Regulation Of Cell Motility Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration Regulation Of Transmembrane Transporter Activity Regulation Of Cellular Component Movement Response To Wounding Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Gamma-aminobutyric Acid Biosynthetic Process Cytosolic Calcium Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Blood Coagulation, Extrinsic Pathway Regulation Of Insulin Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Glutamate Catabolic Process Peptidyl-serine Autophosphorylation
Tagcloud ?			agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?			agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?