TRIM49 and BLM

Number of citations of the paper that reports this interaction (PMID 23708797)
0

Data Source:
BioGRID (enzymatic study)

		TRIM49	BLM
Gene Name		tripartite motif containing 49	Bloom syndrome, RecQ helicase-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Male Germ Cell Nucleus Nucleus Replication Fork Nucleolus Cytoplasm Nuclear Matrix PML Body Pronucleus
	Molecular Function	Zinc Ion Binding	Bubble DNA Binding P53 Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Four-way Junction Helicase Activity ATPase Activity Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding
	Biological Process		Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Strand Renaturation DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To X-ray Replication Fork Processing DNA Duplex Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Negative Regulation Of Mitotic Recombination Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Protection Regulation Of Binding Protein Oligomerization Negative Regulation Of Cell Division Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin
Pathways			Meiotic recombination
Drugs
Diseases
GWAS		Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		1 interactors: BLM	33 interactors: ATM ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 FANCD2 FEN1 MCRS1 MIB1 MLH1 MX1 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN
Entrez ID		57093	641
HPRD ID		05840	05211
Ensembl ID		ENSG00000168930	ENSG00000197299
Uniprot IDs		P0CI25	P54132
PDB IDs			2KV2 2RRD
Enriched GO Terms of Interacting Partners?		Cellular Response To Camptothecin Cellular Response To Hydroxyurea Response To Camptothecin Negative Regulation Of Mitotic Recombination Regulation Of Mitotic Recombination Negative Regulation Of Thymocyte Apoptotic Process Replication Fork Protection DNA Double-strand Break Processing DNA Strand Renaturation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Processing Mitotic G2 DNA Damage Checkpoint Regulation Of Thymocyte Apoptotic Process Negative Regulation Of DNA Recombination Negative Regulation Of T Cell Apoptotic Process Response To X-ray G2 DNA Damage Checkpoint DNA Catabolic Process, Exonucleolytic Cellular Response To Alkaloid Regulation Of T Cell Apoptotic Process Negative Regulation Of DNA Replication Negative Regulation Of Leukocyte Apoptotic Process Cellular Response To Ionizing Radiation Alpha-beta T Cell Differentiation Regulation Of Lymphocyte Apoptotic Process Regulation Of DNA Recombination Alpha-beta T Cell Activation DNA Duplex Unwinding Telomere Maintenance DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Division Recombinational Repair Positive Regulation Of T Cell Proliferation Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA-dependent DNA Replication Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of DNA Replication Cellular Response To Radiation DNA Catabolic Process Cellular Response To Inorganic Substance Regulation Of T Cell Proliferation Response To Ionizing Radiation Response To Alkaloid Double-strand Break Repair DNA Damage Checkpoint	Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Recombination Cell Cycle Response To Stress Cell Cycle Process Organelle Organization Response To Radiation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Aging Telomere Maintenance Nitrogen Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Meiotic Nuclear Division Meiotic Cell Cycle Cell Cycle Checkpoint Response To Abiotic Stimulus Replicative Senescence Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Regulation Of DNA Replication Response To UV Cellular Response To Radiation Mitotic Cell Cycle Protein Sumoylation Metabolic Process DNA Damage Checkpoint DNA Conformation Change Response To Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Aging Regulation Of Cell Cycle Process
Tagcloud ?			bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Difference) ?			bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol
Tagcloud (Intersection) ?