TRIM49 and MINDY3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TRIM49	MINDY3
Description		tripartite motif containing 49	MINDY lysine 48 deubiquitinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nuclear Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K48-linked Deubiquitinase Activity
	Biological Process	Regulation Of Gene Expression Innate Immune Response	Proteolysis Apoptotic Process Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS		Intraocular pressure ( 30591961) Response to taxane treatment (docetaxel) ( 23006423) Serum metabolite levels ( 33031748)
Interacting Genes		4 interacting genes: BLM LGALS8 MINDY3 POM121	10 interacting genes: DAZAP2 MAP3K1 RAD23A RPL8 SDCBP SMURF1 TRIM49 TRIM49C UBC WEE2-AS1
Entrez ID		57093	80013
HPRD ID		05840	10702
Ensembl ID		ENSG00000168930	ENSG00000148481
Uniprot IDs		E9PK69 P0CI25	Q9H8M7
PDB IDs
Enriched GO Terms of Interacting Partners?		8-hydroxy-2'-deoxyguanosine DNA Binding DNA Geometric Change Forked DNA-dependent Helicase Activity Resolution Of DNA Recombination Intermediates Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Four-way Junction Helicase Activity Telomeric D-loop Disassembly Cellular Response To Camptothecin Bubble DNA Binding Y-form DNA Binding G-quadruplex DNA Binding Telomere Maintenance Via Semi-conservative Replication Lymphatic Endothelial Cell Migration Xenophagy Plasma Cell Differentiation Nuclear Membrane T-circle Formation Cellular Response To Hydroxyurea Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides 3'-5' DNA Helicase Activity Lateral Element Negative Regulation Of Cell Division Four-way Junction DNA Binding DNA Conformation Change K48-linked Deubiquitinase Activity Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding DNA Double-strand Break Processing
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