PCNP and UHRF2

Number of citations of the paper that reports this interaction (PMID 12176013)
13

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PCNP	UHRF2
Gene Name		PEST proteolytic signal containing nuclear protein	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nuclear Heterochromatin
	Molecular Function	Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Cycle Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Cell Proliferation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS			Periodontal microbiota ( 22699663)
Protein-Protein Interactions		3 interactors: TERF2IP UBC UHRF2	37 interactors: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 FYN HDAC1 HIST1H3A JAK3 LCK LYN MCL1 PCNA PCNP PTPRC RAD51 RB1 RBCK1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2W USP7 YY1
Entrez ID		57092	115426
HPRD ID		17826	18257
Ensembl ID		ENSG00000081154	ENSG00000147854
Uniprot IDs		Q8WW12	Q96PU4
PDB IDs			1WY8 1Z6U 2E6S 3OLN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Arrest Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cell Cycle Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Notch Receptor Processing Negative Regulation Of DNA Recombination Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Double-strand Break Repair Glycogen Biosynthetic Process Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Protein Localization To Chromosome Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Cell Cycle Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Protein Autoubiquitination Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway DNA Metabolic Process Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress	Response To Stress Cellular Response To Stimulus Response To Stimulus Response To Organic Substance Response To Abiotic Stimulus Regulation Of Immune System Process Signaling Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Signal Transduction Cell Communication Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To DNA Damage Stimulus Regulation Of Cell Proliferation Cellular Response To Stress Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle Process Cell Cycle Phase Transition Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Protein Ubiquitination Positive Regulation Of Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death
Tagcloud ?		autonomy bolster career careers clinicians dissatisfaction held ignore job mailed nationally opinion pcnps pcp pcps professions recommend reimbursement rests satisfied shortage shortages simply slots solve unlikely willingness workforce workplace	aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1
Tagcloud (Difference) ?		autonomy bolster career careers clinicians dissatisfaction held ignore job mailed nationally opinion pcnps pcp pcps professions recommend reimbursement rests satisfied shortage shortages simply slots solve unlikely willingness workforce workplace	aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1
Tagcloud (Intersection) ?