RARB and NCOR2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RARB	NCOR2
Gene Name		retinoic acid receptor, beta	nuclear receptor corepressor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Drug Binding Zinc Ion Binding Protein Complex Binding Retinoid X Receptor Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Histone Deacetylase Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Retinal Pigment Epithelium Development Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Striatum Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters	Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization HDACs deacetylate histones Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs		Adapalene Acitretin Alitretinoin Tazarotene Etretinate TTNPB Tamibarotene
Diseases
GWAS		Airflow obstruction ( 22837378) Obesity (extreme) ( 19553259) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Cognitive performance ( 19734545)
Protein-Protein Interactions		19 interactors: CCNH CEBPA CEBPB EIF3I GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NR4A2 PNRC1 PRKD2 RXRA RXRB RXRG SMAD2 SRC	84 interactors: AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HIST1H4A HNF4A INPP5K IRF5 JUN MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16
Entrez ID		5915	9612
HPRD ID		07183	02910
Ensembl ID		ENSG00000077092	ENSG00000196498
Uniprot IDs		F1D8S6 P10826 Q5QHG3	C9J0Q5 C9JE98 C9JFD3 Q9Y618
PDB IDs		1HRA 1XAP 4DM6 4DM8	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 3R29 3R2A 4A69
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Response To Lipid Regulation Of Gene Expression Gene Expression Regulation Of Transcription, DNA-templated Response To Steroid Hormone Regulation Of Nucleic Acid-templated Transcription Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process In Utero Embryonic Development Macromolecule Biosynthetic Process Cellular Response To Organic Substance Chordate Embryonic Development Intracellular Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Regulation Of Nitrogen Compound Metabolic Process Response To Organic Cyclic Compound Response To Hormone Gland Development Reproductive Structure Development Reproductive System Development Response To Organic Substance Embryo Development Biosynthetic Process Placenta Development System Development Positive Regulation Of Metabolic Process Tissue Development Regulation Of Metabolic Process Cellular Response To Organic Cyclic Compound Organ Development Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Epithelium Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Organic Substance Hormone-mediated Signaling Pathway Steroid Hormone Mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Lipid Cellular Response To Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Response To Lipid Cellular Response To Organic Cyclic Compound Anatomical Structure Development Response To Hormone System Development
Tagcloud ?		activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarg reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarg reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?