RARB

Description		retinoic acid receptor beta
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Population Proliferation Programmed Cell Death Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Bone Development Negative Regulation Of Cartilage Development Neural Precursor Cell Proliferation Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene
Diseases		Small cell lung cancer Non-small cell lung cancer
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Airflow obstruction ( 22837378) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Apolipoprotein A1 levels ( 32203549) Asthma ( 29273806) Bell's palsy ( 33602968) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28448500 28892062 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Calcium levels ( 25972035) Carotid intima media thickness in rheumatoid arthritis ( 30251476) Cataracts ( 34127677) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronotype ( 30696823) Coffee consumption ( 31046077) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Dentures ( 31235808) Dietary macronutrient intake ( 29988085) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 29891935 33627673) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29785010 31959993) Low susceptibility to hepatitis C infection ( 31206233) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Molybdenum levels ( 26025379) Mood instability ( 31168069) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity (extreme) ( 19553259) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Optic disc area ( 31798171 28073927 25631615) Optic disc size ( 31809533) Optic nerve head parameters (multi-trait analysis) ( 31798171) Peak expiratory flow ( 30804560) Platelet distribution width ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NRIP1 PNRC1 PPARGC1A PRKD2 PSMC5 RSPH1 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1
Entrez ID		5915
HPRD ID		07183
Ensembl ID		ENSG00000077092
Uniprot IDs		A0A8I5KWP3 F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5
PDB IDs		1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
Enriched GO Terms of Interacting Partners?		Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Retinoic Acid Receptor Signaling Pathway Regulation Of Primary Metabolic Process DNA-templated Transcription Retinoic Acid-responsive Element Binding DNA Binding Transcription Coactivator Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Chromatin DNA Binding Sequence-specific DNA Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Response To Lipid Nuclear Glucocorticoid Receptor Binding Brahma Complex Transcription Coregulator Activity NpBAF Complex Regulation Of Multicellular Organismal Development NBAF Complex Nuclear Retinoic Acid Receptor Binding Nucleobase-containing Compound Biosynthetic Process Hormone-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding C/EBP Complex DNA-binding Transcription Factor Activity Nucleosome Disassembly
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