PLSCR2 and LCE5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLSCR2	LCE5A
Description		phospholipid scramblase 2	late cornified envelope 5A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Scramblase Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Plasma Membrane Phospholipid Scrambling	Epidermis Development Keratinization
Pathways			Formation of the cornified envelope
Drugs
Diseases
GWAS		Hip circumference ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma and eczema ( 34155719) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Heel bone mineral density x serum urate levels interaction ( 34046847) Inflammatory skin disease ( 25574825)
Interacting Genes		15 interacting genes: AQP1 BSND COQ9 EP300 FAM221B GNG13 HOXA1 LCE1A LCE3A LCE3E LCE5A LYPD1 OTX1 POU4F2 TMEM132D	88 interacting genes: ADAM12 ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 GRN HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-8 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 NUTF2 PLA2G10 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TGFB1 TRIM42 UBE2I VASN VWC2 VWC2L ZNF655
Entrez ID		57047	254910
HPRD ID		09621	17265
Ensembl ID		ENSG00000163746	ENSG00000186207
Uniprot IDs		Q9NRY7	Q5TCM9
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Tissue Development Epidermis Development Sensory Perception Nervous System Process Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Behavioral Defense Response Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Sensory Perception Of Sound Sensory Perception Of Mechanical Stimulus Semicircular Canal Formation Diencephalon Morphogenesis Isoprenoid Binding Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion System Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Abducens Nerve Formation Optokinetic Behavior P53 Binding	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding Protein Binding Phospholipid Scramblase Activity Negative Regulation Of Lens Fiber Cell Differentiation Plasma Membrane Phospholipid Scrambling Cytosol Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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