PSMC3 and DPY30

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PSMC3	DPY30
Description		proteasome 26S subunit, ATPase 3	dpy-30 histone methyltransferase complex regulatory subunit
Image
GO Annotations	Cellular Component	Proteasome Complex P-body Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity Identical Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Blastocyst Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27618452 28739976) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Height ( 23563607 31562340) Hypertension ( 31879980) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29617998 29235454) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (thyroid preparations) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278) Serum albumin levels ( 23022100) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 28739976 27618452) White blood cell count ( 29403010)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		33 interacting genes: AGO2 AMOTL2 ATXN1 CAPN3 CDKN2A CEBPA CKMT1A CKMT1B DPY30 EPM2A ERBB2 F2RL1 FBXO28 FXR1 GADD45A INSIG1 INSIG2 KDM1A MYC NDRG1 NDUFAB1 OGT PSMC3IP PSMC4 PSMC5 STX11 SUMO2 TRAF4 TRAF6 TXNL1 TXNRD2 UBE2I VHL	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		5702	84661
HPRD ID		01733	17434
Ensembl ID		ENSG00000165916	ENSG00000162961
Uniprot IDs		A0A140VK42 P17980	Q9C005
PDB IDs		5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Modification Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Development Negative Regulation Of Hemopoiesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Regulation Of RNA Biosynthetic Process Middle Ear Morphogenesis Regulation Of Kinase Activity SREBP-SCAP-Insig Complex Negative Regulation Of Signal Transduction	Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme
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