PSMC3 and EPM2A

Number of citations of the paper that reports this interaction (PubMedID 26493215)
30

Data Source:
BioGRID (two hybrid)

		PSMC3	EPM2A
Description		proteasome 26S subunit, ATPase 3	EPM2A glucan phosphatase, laforin
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GO Annotations	Cellular Component	Proteasome Complex P-body Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Perikaryon Cytoplasmic Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity Identical Protein Binding	Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Carbohydrate Phosphatase Activity Carbohydrate Binding Polysaccharide Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Glycogen Binding Starch Binding
	Biological Process	Blastocyst Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Protein Catabolic Process	Autophagosome Assembly Regulation Of Cell Growth Glycogen Metabolic Process Glycogen Biosynthetic Process Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Calcium Ion Transport Autophagy Mitochondrion Organization Nervous System Development Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatase Activity Glial Cell Proliferation L-glutamate Transmembrane Transport Wnt Signaling Pathway Positive Regulation Of Macroautophagy Dephosphorylation Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Negative Regulation Of Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Import Into Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Carbohydrate Phosphorylation Habituation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Plasma Membrane
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs		Phenethyl Isothiocyanate
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27618452 28739976) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Height ( 23563607 31562340) Hypertension ( 31879980) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29617998 29235454) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (thyroid preparations) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278) Serum albumin levels ( 23022100) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 28739976 27618452) White blood cell count ( 29403010)	Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252 32888494) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		33 interacting genes: AGO2 AMOTL2 ATXN1 CAPN3 CDKN2A CEBPA CKMT1A CKMT1B DPY30 EPM2A ERBB2 F2RL1 FBXO28 FXR1 GADD45A INSIG1 INSIG2 KDM1A MYC NDRG1 NDUFAB1 OGT PSMC3IP PSMC4 PSMC5 STX11 SUMO2 TRAF4 TRAF6 TXNL1 TXNRD2 UBE2I VHL	15 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		5702	7957
HPRD ID		01733	06345
Ensembl ID		ENSG00000165916	ENSG00000112425
Uniprot IDs		A0A140VK42 P17980	O95278
PDB IDs		5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	4R30 4RKK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Modification Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Macromolecule Metabolic Process Regulation Of Signal Transduction Regulation Of Multicellular Organismal Development Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Development Negative Regulation Of Hemopoiesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Regulation Of RNA Biosynthetic Process Middle Ear Morphogenesis Regulation Of Kinase Activity SREBP-SCAP-Insig Complex Negative Regulation Of Signal Transduction	AMP-activated Protein Kinase Activity Regulation Of Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Glycogen Biosynthetic Process Protein Localization To Lipid Droplet Generation Of Precursor Metabolites And Energy Regulation Of Glycogen Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Carbohydrate Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glycogen Metabolic Process Regulation Of Carbohydrate Catabolic Process Glycogen Binding Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Phosphatase Type 1 Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Glycogen Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Response To Hormone Fatty Acid Biosynthetic Process Response To Glucose Chromatin Remodeling Polysaccharide Biosynthetic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein Phosphatase 1 Binding Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Response To Monosaccharide Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Translation Positive Regulation Of Small Molecule Metabolic Process Response To Carbohydrate Macromolecule Metabolic Process Nuclear Speck Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process
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