MEPE and ZXDC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MEPE	ZXDC
Description		matrix extracellular phosphoglycoprotein	ZXD family zinc finger C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix	Nucleus
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding LRR Domain Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Skeletal System Development Biomineral Tissue Development	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 32981348) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (spine) ( 19801982) Cardiovascular disease risk factors ( 21779381) Dental caries ( 23064961) Gout ( 33832965) Gout vs asymptomatic hyperuricemia ( 33832965) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 22504420) Medication use (drugs affecting bone structure and mineralization) ( 31015401)	Metabolite levels ( 23823483) Pursuit maintenance gain ( 29064472)
Interacting Genes		1 interacting genes: ZXDC	17 interacting genes: APP ATXN1 CBR4 CIITA JTB MEPE MTDH NR1H2 NR1H3 POGZ RORA SH3GL2 SMN1 SUOX TK1 WDR5 ZMYND19
Entrez ID		56955	79364
HPRD ID		06908	14420
Ensembl ID		ENSG00000152595	ENSG00000070476
Uniprot IDs		Q8NC19 Q9NQ76	Q2QGD7
PDB IDs
Enriched GO Terms of Interacting Partners?		LRR Domain Binding C2H2 Zinc Finger Domain Binding	Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cholesterol Storage Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Protein Tetramerization Regulation Of Response To Endoplasmic Reticulum Stress Sterol Homeostasis Cholesterol Homeostasis Phosphatidylcholine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Endocytosis Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Metabolic Process Lipid Homeostasis Positive Regulation Of Cholesterol Transport Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Biosynthetic Process Acylglycerol Homeostasis Negative Regulation Of Inflammatory Response Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Amyloid-beta Complex
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