SLC14A1 and BTN2A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC14A1	BTN2A2
Description		solute carrier family 14 member 1 (Kidd blood group)	butyrophilin subfamily 2 member A2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Water Transmembrane Transporter Activity Protein Binding Urea Transmembrane Transporter Activity Urea Channel Activity	Signaling Receptor Binding Protein Binding
	Biological Process	Water Transport Urea Transport Establishment Of Localization In Cell Transmembrane Transport Urea Transmembrane Transport	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cytokine Production Negative Regulation Of Cytokine Production Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Activated T Cell Proliferation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		SLC-mediated transport of organic cations	Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Bladder cancer ( 21750109 21824976) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Pursuit maintenance gain ( 29064472) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) General cognitive ability ( 29844566) Headache ( 29397368) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver iron content ( 34128465) Neurociticism ( 29500382) Refractive error ( 32231278) Schizophrenia ( 19571809) Smoking initiation ( 33082346) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: BTN2A2 C1GALT1 CFTR FIS1 GIMAP1 MIP RTP2 SNORC STRIT1 THSD7B TMEM97 TMIE	46 interacting genes: AQP6 ARL13B BIK CD53 CD79A CISD2 CREB3 EBP ELOVL4 EMP1 ERGIC3 EVI2B FAM209A FATE1 FFAR2 GJB3 GPR42 GPRC5D GPX8 HSD3B7 KIR2DL3 LHFPL5 LMNA MRM3 MUC1 PEX12 PSMA3 SEC11C SLC10A1 SLC10A6 SLC14A1 SLC16A2 SLC18A1 SLC1A3 SLC30A4 SLC35H1 SLC39A2 SPNS3 STX1A SYT1 TMEM14B TMEM179B TMEM237 TMEM31 TMEM52B TMX2
Entrez ID		6563	10385
HPRD ID		00195	12545
Ensembl ID		ENSG00000141469	ENSG00000124508
Uniprot IDs		B4DFJ8 B4DHU3 F5GWS2 G0W2N5 Q13336	Q8WVV5
PDB IDs		6QD5 8BLP 8XDF	8IH4
Enriched GO Terms of Interacting Partners?		Membrane Water Transport	Membrane Transmembrane Transport Protein Binding Bile Acid:sodium Symporter Activity Clathrin-sculpted Monoamine Transport Vesicle Membrane Neurotransmitter Transport
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