PRSS3 and TFPI

Number of citations of the paper that reports this interaction (PMID 7498454)
4

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		PRSS3	TFPI
Gene Name		protease, serine, 3	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Organelle Membrane Anchored Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Digestion Cobalamin Metabolic Process Zymogen Activation Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Innate Immune System Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Alpha-defensins Defensins Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine Guanidine-3-Propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol	Coagulation factor VIIa Dalteparin
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		3 interactors: APP SERPINA1 TFPI	10 interactors: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		5646	7035
HPRD ID		06685	01064
Ensembl ID		ENSG00000010438	ENSG00000003436
Uniprot IDs		A8CED3 P35030 Q6ISJ4 Q7Z5F4	P10646
PDB IDs		1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4	1ADZ 1IRH 1TFX 4DTG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Platelet Degranulation Response To Wounding Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Methanol Platelet Activation Synaptic Growth At Neuromuscular Junction Response To Triglyceride Collateral Sprouting In Absence Of Injury Response To Chromate Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Exocytosis Negative Regulation Of Serine-type Endopeptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Neuron Remodeling Secretion By Cell Secretion Cellular Copper Ion Homeostasis Cell Activation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Stress Response To Lead Ion Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior	Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Proteolysis Locomotion Cell Migration Movement Of Cell Or Subcellular Component Protein Metabolic Process Cell Motility Wound Healing Response To Wounding Immune System Process Response To Stress Blood Coagulation Hemostasis Catabolic Process Negative Regulation Of Chemotaxis Regulation Of Body Fluid Levels Immune Response Leukocyte Migration Defense Response Endodermal Cell Differentiation Regulation Of Locomotion Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cytokine Biosynthetic Process Platelet Degranulation Negative Regulation Of CGMP-mediated Signaling Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Response To External Stimulus Positive Regulation Of Protein Kinase B Signaling Response To Stimulus Positive Regulation Of Epithelial Cell Migration Endoderm Development Negative Regulation Of Ion Transport Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Fungus Regulation Of Cytokine Biosynthetic Process Regulation Of Protein Kinase B Signaling
Tagcloud ?		3d agar anchorage atypical bioluminescent cationic defines drive find invasive invasiveness isoform malignancy matrigel mediator mesotrypsin microarray modality neither orthotopic prostate prostatectomy proteolytic silencing soft suppress suppresses transwell trypsin	antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic
Tagcloud (Difference) ?		3d agar anchorage atypical bioluminescent cationic defines drive find invasive invasiveness isoform malignancy matrigel mediator mesotrypsin microarray modality neither orthotopic prostate prostatectomy proteolytic silencing soft suppress suppresses transwell trypsin	antithrombin coagulability coagulation epcr f10 f2 f3 f5 f7 g20210a genotypic hemostasis lag leiden procoagulant prothrombin prothrombotic rs12120605 rs1799963 rs2069948 rs3093261 rs6025 rs6427199 rs6427202 rs9332542 snps thrombin thrombotic
Tagcloud (Intersection) ?