PRSS3

Description		serine protease 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Tertiary Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Digestion Antimicrobial Humoral Response Zymogen Activation Endothelial Cell Migration
Pathways		Alpha-defensins Neutrophil degranulation Antimicrobial peptides Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Uptake of dietary cobalamins into enterocytes
Drugs		4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine Diamino-N-[3-(1,3,2-dioxaborolan-2-yloxy)propyl]methaniminium Guanidine-3-propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol
Diseases
GWAS		Bipolar disorder ( 20351715) Hand grip strength ( 29691431) Refractive error ( 32231278) Triglycerides ( 30275531)
Interacting Genes		5 interacting genes: APP LINC00839 PKNOX1 SERPINA1 TFPI
Entrez ID		5646
HPRD ID		06685
Ensembl ID		ENSG00000010438
Uniprot IDs		A0A7P0MP65 P35030 Q7Z5F4
PDB IDs		1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4 4U30 4U32 5C67 5JBT 5TP0 6BX8 6GFI
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Platelet Alpha Granule Lumen Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Coagulation Blood Coagulation Hemostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Hemopoiesis Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting
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