PRSS3

Gene Name		protease, serine, 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Proteolysis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Digestion Cobalamin Metabolic Process Zymogen Activation Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Innate Immune System Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Alpha-defensins Defensins Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine Guanidine-3-Propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol
Diseases
GWAS
Protein-protein Interactions		3 interactors: APP SERPINA1 TFPI
Entrez ID		5646
HPRD ID		06685
Ensembl ID		ENSG00000010438
Uniprot IDs		A8CED3 P35030 Q6ISJ4 Q7Z5F4
PDB IDs		1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Platelet Degranulation Response To Wounding Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Methanol Platelet Activation Synaptic Growth At Neuromuscular Junction Response To Triglyceride Collateral Sprouting In Absence Of Injury Response To Chromate Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Exocytosis Negative Regulation Of Serine-type Endopeptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Neuron Remodeling Secretion By Cell Secretion Cellular Copper Ion Homeostasis Cell Activation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Stress Response To Lead Ion Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior
Tagcloud ?		3d agar anchorage atypical bioluminescent cationic defines drive find invasive invasiveness isoform malignancy matrigel mediator mesotrypsin microarray modality neither orthotopic prostate prostatectomy proteolytic silencing soft suppress suppresses transwell trypsin