PRSS1 and PTPN4

Number of citations of the paper that reports this interaction (PubMedID 8910369)
0

Data Source:
HPRD (in vitro)

		PRSS1	PTPN4
Description		serine protease 1	protein tyrosine phosphatase non-receptor type 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Blood Microparticle	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Hydrolase Activity Glutamate Receptor Binding
	Biological Process	Proteolysis Digestion Extracellular Matrix Disassembly	Protein Dephosphorylation
Pathways		Activation of Matrix Metalloproteinases Uptake of dietary cobalamins into enterocytes Developmental Lineage of Pancreatic Acinar Cells	Toll Like Receptor 4 (TLR4) Cascade Interleukin-37 signaling MECP2 regulates neuronal receptors and channels
Drugs		2H-Benzimidazol-2-amine Bis(5-Amidino-Benzimidazolyl)Methane 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester CRA_17693 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester Hemi-Babim CRA_10991 Monoisopropylphosphorylserine [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone Bis(5-Amidino-2-Benzimidazolyl)Methanone 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 5-Amidino-Benzimidazole Amylamine CRA_16847 Bis-Benzamidine CRA_17312 Zk-806450 [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine CRA-9334 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine CRA_10762 Aminomethylcyclohexane 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine Benzylamine CRA_10655 (1R,2S)-2-Phenylcyclopropanaminium RPR131247 RWJ-56423 CRA_1802 CRA_10972 CRA_1801 [N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidine Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 CRA_10433 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone 4-Fluorobenzylamine RWJ-51084 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea ZK-806711 3,5-Diiodotyrosine (2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acid bis(5-amidino-benzimidazolyl)methanone zinc CRA_11092 CRA_9785 Diminazene CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine Phosphorylisopropane Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine CRA_9076 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid CRA_23653 Cyclotheonamide A Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate 4-Phenylbutylamine Phenethylamine 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Aeruginosin 98-B 3-Phenylpropylamine RPR128515 ZK-805623 Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminium Benzo[B]Thiophene-2-Carboxamidine CRA_10656 CRA_9678 4-PIPERIDIN-4-YLBUTANAL 2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitol 2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL 2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL 1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitol Aprotinin diethyl [(1R)-1,5-diaminopentyl]boronate (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE 2-Naphthalenesulfonic acid 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE Nafamostat Camostat	Alendronic acid
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779) Cancer ( 29299148) Meconium ileus in cystic fibrosis ( 30807572) Methadone dose in opioid dependence ( 28115739) Pancreatitis ( 23143602)	Lymphocyte count ( 32888494)
Interacting Genes		11 interacting genes: DEFA5 LINC00839 PTPN4 RNF26 SERPINA1 SERPINB13 SERPINB8 SERPINF2 SPINK5 TST UBE3A	13 interacting genes: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL MAPK12 PRSS1 TK1 VANGL2 ZZEF1
Entrez ID		5644	5775
HPRD ID		02039	01471
Ensembl ID		ENSG00000204983	ENSG00000088179
Uniprot IDs		P07477	P29074
PDB IDs		1FXY 1TRN 2RA3 4WWY 4WXV 7QE8 7QE9 8H3S	2CS5 2I75 2VPH 3NFK 3NFL 5EYZ 5EZ0 7VZE
Enriched GO Terms of Interacting Partners?		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Negative Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Endopeptidase Activity Protease Binding Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Extracellular Space Acute-phase Response Negative Regulation Of Hydrolase Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Keratinocyte Apoptotic Process Endopeptidase Inhibitor Activity Sperm Entry Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of Antibacterial Peptide Production Acute Inflammatory Response Platelet Alpha Granule Lumen Cyanate Catabolic Process 3-mercaptopyruvate Sulfurtransferase Activity RRNA Transport Thiosulfate-cyanide Sulfurtransferase Activity RRNA Import Into Mitochondrion Regulation Of Golgi Lumen Acidification	DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Protein Localization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Metal Ion Binding Post-embryonic Forelimb Morphogenesis Chromosome, Subtelomeric Region Signal Transduction In Response To DNA Damage Regulation Of Organelle Organization Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Scaffold Protein Binding Response To Cholecystokinin Translational Elongation Translation Elongation Factor Activity Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Excitatory Postsynaptic Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Triglyceride Metabolic Process Thymidine Kinase Activity Histone H2AK5 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Cerebellar Neuron Development Directional Locomotion Acylglycerol Metabolic Process Neutral Lipid Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Histone H2A Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Protein Localization To Chromosome Signal Transduction By P53 Class Mediator Cellular Developmental Process Positive Regulation Of Chromosome Organization Kinase Binding
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