PRSS1 and SPINK5

Number of citations: 0 (PubMedID 10419450)
Data Source: HPRD (in vitro)

		PRSS1	SPINK5
Name		serine protease 1	serine peptidase inhibitor Kazal type 5
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Blood Microparticle	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cell Cortex Perinuclear Region Of Cytoplasm Epidermal Lamellar Body
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Proteolysis Digestion Extracellular Matrix Disassembly	Negative Regulation Of Antibacterial Peptide Production Epidermal Cell Differentiation Negative Regulation Of Angiogenesis Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Epithelial Cell Differentiation Hair Cell Differentiation Regulation Of T Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Immune Response Regulation Of Timing Of Anagen
Pathways		Activation of Matrix Metalloproteinases Uptake of dietary cobalamins into enterocytes Developmental Lineage of Pancreatic Acinar Cells	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		2H-Benzimidazol-2-amine Bis(5-Amidino-Benzimidazolyl)Methane 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester CRA_17693 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester Hemi-Babim CRA_10991 Monoisopropylphosphorylserine [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone Bis(5-Amidino-2-Benzimidazolyl)Methanone 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 5-Amidino-Benzimidazole Amylamine CRA_16847 Bis-Benzamidine CRA_17312 Zk-806450 [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine CRA-9334 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine CRA_10762 Aminomethylcyclohexane 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine Benzylamine CRA_10655 (1R,2S)-2-Phenylcyclopropanaminium RPR131247 RWJ-56423 CRA_1802 CRA_10972 CRA_1801 [N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidine Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 CRA_10433 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone 4-Fluorobenzylamine RWJ-51084 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea ZK-806711 3,5-Diiodotyrosine (2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acid bis(5-amidino-benzimidazolyl)methanone zinc CRA_11092 CRA_9785 Diminazene CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine Phosphorylisopropane Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine CRA_9076 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid CRA_23653 Cyclotheonamide A Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate 4-Phenylbutylamine Phenethylamine 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Aeruginosin 98-B 3-Phenylpropylamine RPR128515 ZK-805623 Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminium Benzo[B]Thiophene-2-Carboxamidine CRA_10656 CRA_9678 4-PIPERIDIN-4-YLBUTANAL 2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitol 2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL 2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL 1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitol Aprotinin diethyl [(1R)-1,5-diaminopentyl]boronate (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE 2-Naphthalenesulfonic acid 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE Nafamostat Camostat	None
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis	Netherton syndrome
GWAS		Alcoholic chronic pancreatitis ( 28754779 ) Cancer ( 29299148 ) Meconium ileus in cystic fibrosis ( 30807572 ) Methadone dose in opioid dependence ( 28115739 ) Pancreatitis ( 23143602 )	Blood protein levels ( 30072576 )
Novel Interactors		2 novel interactors: MRPS33 SHANK2	None recorded
Interacting Genes		11 interacting genes: DEFA5 LINC00839 PTPN4 RNF26 SERPINA1 SERPINB13 SERPINB8 SERPINF2 SPINK5 TST UBE3A	1 interacting genes: PRSS1
Entrez ID		5644	11005
HPRD ID		02039	05423
Ensembl ID		ENSG00000204983	ENSG00000133710
Uniprot IDs		P07477	Q9NQ38
PDB IDs		1FXY 1TRN 2RA3 4WWY 4WXV 7QE8 7QE9 8H3S	1H0Z 1HDL 1UUC 1UVF 1UVG 5YHN
GO Terms Enriched among Interactors		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Negative Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Endopeptidase Activity Protease Binding Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Extracellular Space Acute-phase Response Negative Regulation Of Hydrolase Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Keratinocyte Apoptotic Process Endopeptidase Inhibitor Activity Sperm Entry Positive Regulation Of Golgi Lumen Acidification Negative Regulation Of Antibacterial Peptide Production Acute Inflammatory Response Platelet Alpha Granule Lumen Cyanate Catabolic Process 3-mercaptopyruvate Sulfurtransferase Activity RRNA Transport Thiosulfate-cyanide Sulfurtransferase Activity RRNA Import Into Mitochondrion Regulation Of Golgi Lumen Acidification	Digestion Extracellular Matrix Disassembly Serine-type Peptidase Activity Serine-type Endopeptidase Activity Blood Microparticle Extracellular Structure Organization Extracellular Matrix Organization